{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T03:16:48Z","timestamp":1762917408784,"version":"3.37.3"},"reference-count":25,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2012,7,22]],"date-time":"2012-07-22T00:00:00Z","timestamp":1342915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:p><jats:bold>Aim\u2002<\/jats:bold> The aim of the study was to describe seizure outcome following surgery for focal extratemporal epilepsy and identify factors associated with prolonged postsurgical freedom from seizures.<\/jats:p><jats:p><jats:bold>Method\u2002<\/jats:bold> In this retrospective cohort study, children with drug\u2010resistant focal extratemporal epilepsy were treated surgically and followed up in a single tertiary care centre between 1997 and 2008.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Eighty children were identified for inclusion in the study (42 males, 38 females; median age 9y 1mo, range 3mo\u201318y 7mo). The aetiology was identified as focal cortical dysplasia (<jats:italic>n<\/jats:italic>=37), low\u2010grade tumour (<jats:italic>n<\/jats:italic>=22), tuberous sclerosis (<jats:italic>n<\/jats:italic>=9), or non\u2010specific (<jats:italic>n<\/jats:italic>=12). Children were followed for a median of 3\u2003years 1\u2003month (range 8mo\u201310y 7mo) after surgery. Overall, at last follow\u2010up, 50% of the children had been completely seizure free since surgery (Engel class Ia); of these 40 individuals, 15 had discontinued all antiepileptic drugs. Several presurgical factors were associated with a favourable outcome. However, after controlling for confounding factors, aetiology appeared to be the only determinant of long\u2010term seizure outcome as non\u2010specific lesion pathology was associated with seizure recurrence (hazard ratio 10.43; 95% confidence interval 3.26\u201333.39).<\/jats:p><jats:p><jats:bold>Interpretation\u2002<\/jats:bold> In 50% of cases, children with surgically treated drug\u2010resistant extratemporal epilepsies have an excellent long\u2010term outcome. The aetiology of the epileptogenic lesion appears to be the only significant determinant of surgical outcome in this population of children. It is difficult to correctly identify non\u2010specific pathology on presurgical magnetic resonance imaging.<\/jats:p>","DOI":"10.1111\/j.1469-8749.2012.04381.x","type":"journal-article","created":{"date-parts":[[2012,7,23]],"date-time":"2012-07-23T01:25:37Z","timestamp":1343006737000},"page":"995-1000","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Seizure outcome after extratemporal epilepsy surgery in childhood"],"prefix":"10.1111","volume":"54","author":[{"given":"LUIGI","family":"D\u2019ARGENZIO","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M CHIARA","family":"COLONNELLI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SUE","family":"HARRISON","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"THOMAS S","family":"JACQUES","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"WILLIAM","family":"HARKNESS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ROD C","family":"SCOTT","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J HELEN","family":"CROSS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,7,22]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2007.01421.x"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11940-004-0017-4"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2009.02239.x"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2009.07.018"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2010.05.002"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-007-0545-9"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-006-0085-8"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2003.07.005"},{"key":"e_1_2_8_10_2","first-page":"609","volume-title":"Surgical Treatment of the Epilepsies","author":"Engel J","year":"1993"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2011.03272.x"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2012.04293.x"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000176055.45774.71"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-009-1056-7"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2008.01538.x"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.3171\/JNS\/2008\/108\/4\/0676"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000334365.22854.d3"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-006-0309-6"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2009.07.007"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2007.01428.x"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.3171\/PED\/2008\/1\/4\/277"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410440507"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1999.tb01591.x"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2008.01969.x"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2007.116038"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2002-23595"}],"container-title":["Developmental Medicine &amp; 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