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As <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>lack <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>mericans have an increased risk of hypertension, we evaluated associations between <jats:styled-content style=\"fixed-case\">\u03b1<jats:sub>1A<\/jats:sub>\u2010AR<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">Arg492Cys<\/jats:styled-content>), <jats:styled-content style=\"fixed-case\">\u03b1<jats:sub>2A<\/jats:sub>\u2010AR<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">\u20101291C\/G<\/jats:styled-content>), and <jats:styled-content style=\"fixed-case\">\u03b1<jats:sub>2B<\/jats:sub>\u2010AR<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">Ins\/Del301\u2010303<\/jats:styled-content>) gene variants and cardiovascular reactivity in 500 normotensive <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>lack youth. Heart rate, preejection period, total peripheral resistance, and blood pressure were measured during cold and psychological stress. The <jats:styled-content style=\"fixed-case\">Arg492Cys<\/jats:styled-content> polymorphism in the <jats:styled-content style=\"fixed-case\">\u03b1<jats:sub>1A<\/jats:sub>\u2010AR<\/jats:styled-content> gene was associated with heart rate reactivity to stress, but the association depended on sex. The <jats:styled-content style=\"fixed-case\">\u20101291C\/G<\/jats:styled-content> promoter polymorphism in the <jats:styled-content style=\"fixed-case\">\u03b1<jats:sub>2A<\/jats:sub>\u2010AR<\/jats:styled-content> gene was associated with vascular reactivity to stress; vasoconstriction increased as a linear function of the number of copies of the variant <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content> allele. Thus, specific associations emerged between genetic variations in <jats:styled-content style=\"fixed-case\">\u03b1\u2010Ars<\/jats:styled-content> and cardiovascular reactivity in young <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>lacks.<\/jats:p>","DOI":"10.1111\/j.1469-8986.2011.01319.x","type":"journal-article","created":{"date-parts":[[2011,11,15]],"date-time":"2011-11-15T02:02:10Z","timestamp":1321322530000},"page":"401-412","source":"Crossref","is-referenced-by-count":22,"title":["Alpha\u2010adrenergic receptor gene polymorphisms and cardiovascular reactivity to stress in <scp>B<\/scp>lack adolescents and young adults"],"prefix":"10.1111","volume":"49","author":[{"given":"Robert M.","family":"Kelsey","sequence":"first","affiliation":[{"name":"Department of Pediatrics University of Tennessee Health Science Center  Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce S.","family":"Alpert","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Tennessee Health Science Center  Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary K.","family":"Dahmer","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Medical College of Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Krushkal","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine University of Tennessee Health Science Center  Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael W.","family":"Quasney","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Medical College of Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,11,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006842-199311000-00006"},{"key":"e_1_2_6_3_1","first-page":"69","article-title":"Validation of CAS Model 9010 automated blood pressure monitor: Children\/adult and neonatal studies","volume":"1","author":"Alpert B. 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