{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T06:06:13Z","timestamp":1776146773712,"version":"3.50.1"},"reference-count":10,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2005,8,19]],"date-time":"2005-08-19T00:00:00Z","timestamp":1124409600000},"content-version":"vor","delay-in-days":5405,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[1990,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p> <jats:italic>Objective<\/jats:italic>\u2013To investigate the efficacy of ethacridine lactate by the extraamniotic route for second trimester pregnancy termination and its associated complications.<\/jats:p><jats:p> <jats:italic>Design<\/jats:italic>\u2013Retrospective study of women undergoing second trimester termination, over 3\u00bd years, with extra\u2010amniotic ethacridine alone, or extra\u2010amniotic ethacridine supplemented later by extra\u2010amniotic 15\u2010methyl prostaglandin F,\u03b1.<\/jats:p><jats:p> <jats:italic>Setting<\/jats:italic>\u2013Teaching hospital in Bombay.<\/jats:p><jats:p> <jats:italic>Patients<\/jats:italic>\u2013315 consecutive women undergoing late abortions with extraamniotic ethacridine. Demographic features were similar in the two groups.<\/jats:p><jats:p> <jats:italic>Interventions<\/jats:italic>\u2013In group 1, 207 women had 150ml of 0.1% ethacridine lactate injected slowly into the extra\u2010amniotic space. In group 2, 108 women had the initial injection supplemented 6 h later by an extra\u2010amniotic injection of 250 \u03bc.g (1 ml) of 15\u2010methyl prostaglandin F<jats:sub>2\u03b1<\/jats:sub>.<\/jats:p><jats:p> <jats:italic>Main outcome measures<\/jats:italic>\u2013The occurrence of abortion following the induction procedure. The development of complications such as haemorrhage, infection, or injury to the uterus or cervix.<\/jats:p><jats:p> <jats:italic>Results<\/jats:italic>\u2013The method was successful in 191 women (92%) in group 1 and in 106 (98%) in group 2. The median induction\u2010abortion intervals were 35 and 19 h, respectively (Mann\u2010Whitney U test, P&lt;0.001). The corrected complication rate was &lt;10% (30 women), with unplanned uterine evacuation in 6% (20), haemorrhage in 1% (4), and pelvic infection in 4% (14).<\/jats:p><jats:p> <jats:italic>Conclusion<\/jats:italic>\u2013The use of extra\u2010amniotic ethacridine lactate provides an effective and safe treatment method for second trimester legal abortion. The inductionabortion interval can be appreciably reduced by supplementary prostaglandin.<\/jats:p>","DOI":"10.1111\/j.1471-0528.1990.tb02476.x","type":"journal-article","created":{"date-parts":[[2005,8,19]],"date-time":"2005-08-19T15:08:51Z","timestamp":1124464131000},"page":"1026-1029","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Second trimester pregnancy termination using extraamniotic ethacridine lactate"],"prefix":"10.1111","volume":"97","author":[{"given":"R. K.","family":"BHATHENA","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. K.","family":"SHERIAR","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V. R.","family":"WALVEKAR","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"GUILLEBAUD","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,8,19]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"88","article-title":"Early complications and sequelae of pregnancy interruption with hypertonic saline","volume":"25","author":"Borcnstcin R.","year":"1980","journal-title":"Int J Fertil"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/01443618709068525"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-407-01720-7.50018-7"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1989.tb06307.x"},{"key":"e_1_2_1_6_1","first-page":"55","volume-title":"Second Trimester Pregnancy Termination","author":"Ingemanson C.","year":"1980"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/S0002-9378(15)33120-3","article-title":"Five thousand consecutive saline inductions","volume":"116","author":"Kcrcnyi T. D.","year":"1973","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/0002-9378(69)90172-0","article-title":"Artificial abortion at mid\u2010pregnancy by mechanical stimulation of the uterus","volume":"105","author":"Manabc Y.","year":"1969","journal-title":"Am J Obsld Gynecol"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/0002-9378(71)90214-6","article-title":"Extraovular transcervical injection of rivanol tor interruption of pregnancy","volume":"110","author":"Nabriski S. A.","year":"1971","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_2_1_10_1","first-page":"137","volume-title":"Techniques of Abortion","author":"Neubart S.","year":"1972"},{"key":"e_1_2_1_11_1","first-page":"59","volume-title":"Late Abortions in England and Wales\u2013 Report of a National Confidential Study","author":"Stanwell\u2010Smith R.","year":"1984"}],"container-title":["BJOG: An International Journal of Obstetrics &amp; Gynaecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1471-0528.1990.tb02476.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1471-0528.1990.tb02476.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T18:33:41Z","timestamp":1697999621000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/j.1471-0528.1990.tb02476.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,11]]},"references-count":10,"journal-issue":{"issue":"11","published-print":{"date-parts":[[1990,11]]}},"alternative-id":["10.1111\/j.1471-0528.1990.tb02476.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1471-0528.1990.tb02476.x","archive":["Portico"],"relation":{},"ISSN":["1470-0328","1471-0528"],"issn-type":[{"value":"1470-0328","type":"print"},{"value":"1471-0528","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,11]]},"assertion":[{"value":"2005-08-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}