{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T08:54:44Z","timestamp":1790240084825,"version":"4.1.0"},"reference-count":17,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2003,12,22]],"date-time":"2003-12-22T00:00:00Z","timestamp":1072051200000},"content-version":"vor","delay-in-days":904,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2001,7]]},"abstract":"<jats:p><jats:bold>Objective<\/jats:bold> To evaluate the effect of human chorionic gonadotrophin (hCG) on pregnant human myometrial contractility <jats:italic>in vitro<\/jats:italic> and to determine whether the hCG\u2010elicited effect was oestrogen dependant.<\/jats:p><jats:p><jats:bold>Methods<\/jats:bold> Isometric tension recording was performed under physiological conditions in isolated myometrial strips from biopsies obtained at elective caesarean section. The effect of cumulative additions of hCG (0.001, 0.01, 0.1, 1.0 and 10 iu\/mL) on myometrial contractility was evaluated. Secondarily, the contractile activity of pregnant myometrium following hCG exposure was investigated in tissue pre\u2010treated with beta\u2010oestradiol.<\/jats:p><jats:p><jats:bold>Results<\/jats:bold> hCG exerted a statistically significant relaxant effect on pregnant human myometrial tissue. The relaxant effect increased with increasing concentrations of hCG from 8.96% (SEM 2.06) (0.001 iu\/mL hCG; <jats:italic>P<\/jats:italic>&lt;0.01) to a net cumulative total of 58.50% (SEM 3.74) (10 iu\/mL hCG; <jats:italic>P<\/jats:italic>&lt;0.01). The relaxant effect was also time\u2010dependant, increasing in magnitude throughout the duration of experiments. Beta\u2010oestradiol did not significantly affect the response of myometrial tissue to hCG.<\/jats:p><jats:p><jats:bold>Conclusions<\/jats:bold> These results clearly demonstrate that hCG exerts a significant concentration\u2010dependant relaxant effect on human myometrial tissue obtained rate in pregnancy. These findings outline an inhibitory physiological role of hCG on human myometrial contractility and raise the possibility of its potential use as a tocolytic.<\/jats:p>","DOI":"10.1111\/j.1471-0528.2001.00178.x","type":"journal-article","created":{"date-parts":[[2003,12,22]],"date-time":"2003-12-22T17:21:28Z","timestamp":1072113688000},"page":"704-708","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Human chorionic gonadotrophin inhibition of pregnant human myometrial contractility"],"prefix":"10.1111","volume":"108","author":[{"given":"Michael M.","family":"Slattery","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cara","family":"Brennan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"O'Leary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"Morrison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,12,22]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.50.070181.002341"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.79.3.907"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.135.6.2772"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0920425"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.79.6.1582"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(99)70313-3"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(00)00718-3"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(93)90294-S"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2001.110695"},{"key":"e_1_2_6_11_2","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/0002-9378(76)90518-4","article-title":"Serum human chorionic gonadotrophin levels throughout normal pregnancy","volume":"15","author":"Braunstein G.D.","year":"1976","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-7061(99)00125-9"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(00)00718-3"},{"key":"e_1_2_6_14_2","first-page":"374","article-title":"In vitro comparison of four tocolytic agents, alone or in combination","volume":"84","author":"Saade G.R.","year":"1994","journal-title":"Obstet Gynecol"},{"key":"e_1_2_6_15_2","first-page":"483","article-title":"Effects of nitric oxide (NO) substrate, NO donor compounds and NO synthase inhibitors on contractions of isolated human pregnant myometrium","volume":"103","author":"Morrison J.J.","year":"1996","journal-title":"Br J Obstet Gynaecol"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo-99-6-1562"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0660371"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2000.tb11626.x"}],"container-title":["BJOG: An International Journal of Obstetrics &amp; Gynaecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1471-0528.2001.00178.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1471-0528.2001.00178.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T06:38:06Z","timestamp":1697524686000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/j.1471-0528.2001.00178.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,7]]},"references-count":17,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2001,7]]}},"alternative-id":["10.1111\/j.1471-0528.2001.00178.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1471-0528.2001.00178.x","archive":["Portico"],"relation":{},"ISSN":["1470-0328","1471-0528"],"issn-type":[{"value":"1470-0328","type":"print"},{"value":"1471-0528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,7]]},"assertion":[{"value":"2003-12-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}