{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T05:25:58Z","timestamp":1697520358172},"reference-count":33,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2003,12,22]],"date-time":"2003-12-22T00:00:00Z","timestamp":1072051200000},"content-version":"vor","delay-in-days":812,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2001,10]]},"abstract":"<jats:p><jats:bold>Objective\n\t\t\t\t\t<\/jats:bold> To investigate the relationship between breech presentation, external cephalic version and levels of cord blood thyroid stimulating hormone.<\/jats:p><jats:p><jats:bold>Design\n\t\t\t\t\t<\/jats:bold> Case\u2013control study.<\/jats:p><jats:p><jats:bold>Setting\n\t\t\t\t\t<\/jats:bold> University teaching hospital.<\/jats:p><jats:p><jats:bold>Population\n\t\t\t\t\t<\/jats:bold> The study group consisted of 289 consecutive singleton deliveries at term over a four\u2010year period, all of whom had an attempt at external cephalic version performed near term for breech presentation. The control group included 23,001 singleton term deliveries during the same four\u2010year period.<\/jats:p><jats:p><jats:bold>Methods\n\t\t\t\t\t<\/jats:bold> Between group differences were compared with the Mann\u2010Whitney <jats:italic>U<\/jats:italic> test or <jats:styled-content><jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup><\/jats:styled-content> test when appropriate.<\/jats:p><jats:p><jats:bold>Main outcome measures\n\t\t\t\t\t<\/jats:bold> Levels of cord blood thyroid stimulating hormone and the incidence of false positive screening results for congenital hypothyroidism.<\/jats:p><jats:p><jats:bold>Results\n\t\t\t\t\t<\/jats:bold> Babies who were born vaginally after prior successful external cephalic version had significantly higher median levels of cord blood thyroid stimulating hormone (6.4 <jats:italic>vs<\/jats:italic> 6.0mIU\/L, <jats:italic>P<\/jats:italic>=0.034) and the incidence of false positive screening for thyroid stimulating hormone (12.9%<jats:italic>vs<\/jats:italic> 7.2%, <jats:styled-content><jats:italic>P<\/jats:italic>=0.016, OR 1.9<\/jats:styled-content>) compared with babies with spontaneous cephalic presentation. In babies with a breech presentation born by elective caesarean section, previous attempts at external cephalic version had no effect on cord blood thyroid stimulating hormone levels. There was also no difference in the levels of cord blood thyroid stimulating hormone between cephalic and breech\u2010presenting fetuses born by elective caesarean section. However, breech\u2010presenting babies born by emergency caesarean section after onset of labour had higher median levels of cord thyroid stimulating hormone than those with cephalic presentation (5.1 <jats:italic>vs<\/jats:italic> 4.5 mIU\/L, <jats:italic>P<\/jats:italic>=0.008).<\/jats:p><jats:p><jats:bold>Conclusion\n\t\t\t\t\t<\/jats:bold> Levels of cord blood thyroid stimulating hormone are elevated in babies born vaginally after a successful external cephalic version. This finding may represent a biological difference in fetal response to the stress of labour in breech\u2010presenting fetuses, which is not correctable by a successful external cephalic version.<\/jats:p>","DOI":"10.1111\/j.1471-0528.2001.00256.x","type":"journal-article","created":{"date-parts":[[2003,12,22]],"date-time":"2003-12-22T16:58:21Z","timestamp":1072112301000},"page":"1076-1080","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Levels of cord blood thyroid stimulating hormone after external cephalic version"],"prefix":"10.1111","volume":"108","author":[{"given":"Louis","family":"Yik\u2010Si Chan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tze","family":"Kin Lau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pui","family":"Yu Chiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary","family":"Wing\u2010KinWong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tse Ngong","family":"Leung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,12,22]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/scientificamerican0495-124"},{"key":"e_1_2_5_3_2","first-page":"1095","article-title":"Collaborative: effects of neonatal screening for hypothyroidism. 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