{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T06:52:56Z","timestamp":1697611976731},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2003,12,22]],"date-time":"2003-12-22T00:00:00Z","timestamp":1072051200000},"content-version":"vor","delay-in-days":689,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2002,2]]},"abstract":"<jats:p><jats:bold>Objective\n\t\t\t\t\t<\/jats:bold> To compare the prevalence of the Factor V Leiden mutation in children and maternal\u2013infant pairs in pregnancies affected by severe pre\u2010eclampsia with unmatched normal controls.<\/jats:p><jats:p><jats:bold>Design\n\t\t\t\t\t<\/jats:bold> Prospective cohort study.<\/jats:p><jats:p><jats:bold>Setting\n\t\t\t\t\t<\/jats:bold> Department of Women's and Children's Health, The Canberra Hospital, Garran, ACT, Australia.<\/jats:p><jats:p><jats:bold>Sample\n\t\t\t\t\t<\/jats:bold> Forty\u2010eight maternal\u2013infant pairs where the index pregnancy was affected by severe pre\u2010eclampsia; 46 unmatched maternal\u2013infant pairs where the index pregnancy was defined as normal.<\/jats:p><jats:p><jats:bold>Methods\n\t\t\t\t\t<\/jats:bold> DNA analysis of cheek swab samples obtained from maternal\u2013infant pairs for the Factor V Leiden mutation.<\/jats:p><jats:p><jats:bold>Main outcome measure\n\t\t\t\t\t<\/jats:bold> The prevalence of the Factor V Leiden mutation in mothers, infants and maternal\u2013infant pairs in association with severe pre\u2010eclampsia compared with unmatched controls.<\/jats:p><jats:p><jats:bold>Results\n\t\t\t\t\t<\/jats:bold> No difference was detected in the prevalence of Factor V Leiden mutation between the women and children of both groups, nor the maternal\u2013infant pairs from each group.<\/jats:p><jats:p><jats:bold>Conclusions\n\t\t\t\t\t<\/jats:bold> No evidence was found of an increased prevalence of the Factor V Leiden mutation in either the mothers or children in association with severe pre\u2010eclampsia. 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