{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T01:58:17Z","timestamp":1794362297577,"version":"4.9.0"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2003,12,22]],"date-time":"2003-12-22T00:00:00Z","timestamp":1072051200000},"content-version":"vor","delay-in-days":689,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2002,2]]},"abstract":"<jats:p><jats:bold>Objective\n\t\t\t\t\t<\/jats:bold> To evaluate the efficacy of low\u2010dose acetylsalicylic acid in the prevention of pregnancy\u2010induced hypertension and intrauterine growth retardation in high\u2010risk pregnancies as determined by transvaginal Doppler ultrasound study of the uterine arteries at 12 to 14 weeks of gestation.<\/jats:p><jats:p><jats:bold>Design\n\t\t\t\t\t<\/jats:bold> Randomised, double blind and placebo\u2010controlled trial.<\/jats:p><jats:p><jats:bold>Setting\n\t\t\t\t\t<\/jats:bold> The Department of Obstetrics and Gynaecology, Tampere University Hospital, Finland.<\/jats:p><jats:p><jats:bold>Population\n\t\t\t\t\t<\/jats:bold> One hundred and twenty pregnant women considered to be at high risk of pre\u2010eclampsia or intrauterine growth retardation were screened by transvaginal Doppler ultrasound at 12 to 14 weeks of gestation.<\/jats:p><jats:p><jats:bold>Methods\n\t\t\t\t\t<\/jats:bold> Ninety pregnant women with bilateral notches in the uterine arteries were randomised to receive acetylsalicyclic acid 0.5mg\/kg\/day (<jats:styled-content><jats:italic>n<\/jats:italic>= 45<\/jats:styled-content>) or placebo (<jats:styled-content><jats:italic>n<\/jats:italic>= 45<\/jats:styled-content>) from 12 to 14 weeks of gestation.<\/jats:p><jats:p><jats:bold>Main outcome measures\n\t\t\t\t\t<\/jats:bold> Hypertensive disorders of pregnancy and intrauterine growth retardation.<\/jats:p><jats:p><jats:bold>Results\n\t\t\t\t\t<\/jats:bold> Forty\u2010three women on acetylsalicyclic acid and 43 on placebo were successfully followed up. The use of acetylsalicyclic acid was associated with a statistically significant reduction in the incidence of pregnancy\u2010induced hypertension (<jats:styled-content>11.6%<jats:italic>vs<\/jats:italic> 37.2%, RR = 0.31, 95% CI 0.13\u20130.78<\/jats:styled-content>) and pre\u2010eclampsia (<jats:styled-content>4.7%<jats:italic>vs<\/jats:italic> 23.3%, RR = 0.2, 95% CI 0.05\u20130.86<\/jats:styled-content>). The incidence of hypertension before 37 weeks of pregnancy was also significantly reduced (<jats:styled-content>2.3%<jats:italic>vs<\/jats:italic> 20.9%, RR = 0.22, 95% CI 0.05\u20130.97<\/jats:styled-content>). The reduction in the incidence of intrauterine growth retardation (2.3%<jats:italic>vs<\/jats:italic> 7%) was not statistically significant. Acetylsalicyclic acid was not associated with excess risk of maternal or fetal bleeding.<\/jats:p><jats:p><jats:bold>Conclusion\n\t\t\t\t\t<\/jats:bold> In women rated in Doppler velocimetry waveform analysis to be at high risk of pre\u2010eclampsia, low\u2010dose acetylsalicyclic acid reduces the incidence of pregnancy\u2010induced hypertension and especially proteinuric pre\u2010eclampsia.<\/jats:p>","DOI":"10.1111\/j.1471-0528.2002.01046.x","type":"journal-article","created":{"date-parts":[[2003,12,22]],"date-time":"2003-12-22T16:34:07Z","timestamp":1072110847000},"page":"161-167","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":116,"title":["Low dose acetylsalicylic acid in prevention of pregnancy\u2010induced hypertension and intrauterine growth retardation in women with bilateral uterine artery notches"],"prefix":"10.1111","volume":"109","author":[{"given":"Merja","family":"Vainio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erkki","family":"Kujansuu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marja","family":"Iso\u2010Mustaj\u00e4rvi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juhani","family":"M\u00e4enp\u00e4\u00e4","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,12,22]]},"reference":[{"key":"e_1_2_16_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(85)80223-4"},{"key":"e_1_2_16_3_2","first-page":"122","article-title":"Preeclampsia: a review of the role of prostaglandins","volume":"71","author":"Friedman SA","year":"1988","journal-title":"Obstet Gynecol"},{"key":"e_1_2_16_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198908103210604"},{"key":"e_1_2_16_5_2","first-page":"551","article-title":"Low\u2010dose aspirin in pregnancy","volume":"74","author":"Sibai BM","year":"1989","journal-title":"Obstet Gynecol"},{"key":"e_1_2_16_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)92207-X"},{"key":"e_1_2_16_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)91891-X"},{"key":"e_1_2_16_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(88)91198-1"},{"key":"e_1_2_16_9_2","first-page":"619","article-title":"CLASP: a randomised trial of low\u2010dose aspirin for the prevention and treatment of pre\u2010eclampsia among 9364 pregnant women","volume":"341","author":"CLASP Collaborative Group","year":"1993","journal-title":"Lancet"},{"key":"e_1_2_16_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)92988-6"},{"key":"e_1_2_16_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1996.tb09513.x"},{"key":"e_1_2_16_12_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2000.00061.x"},{"key":"e_1_2_16_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(80)90387-7"},{"key":"e_1_2_16_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1986.tb07830.x"},{"key":"e_1_2_16_15_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1997.09020094.x"},{"key":"e_1_2_16_16_2","unstructured":"ACOG Technical Bulletin.Hypertension in Pregnancy Number 219\u2010January 1996"},{"key":"e_1_2_16_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)64469-8"},{"key":"e_1_2_16_18_2","first-page":"500","article-title":"Is mild preeclampsia (EPH gestosis) harmful to the baby","volume":"112","author":"MacGillivray I","year":"1976","journal-title":"Is J Med Sci"},{"key":"e_1_2_16_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)90889-O"},{"key":"e_1_2_16_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1998.tb09971.x"},{"key":"e_1_2_16_21_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0412.1999.780202.x"},{"key":"e_1_2_16_22_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI110576"},{"key":"e_1_2_16_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)93124-R"},{"key":"e_1_2_16_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1997.tb11977.x"},{"key":"e_1_2_16_25_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2000.00288.x"}],"container-title":["BJOG: An International Journal of Obstetrics &amp; 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