{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T05:46:23Z","timestamp":1789451183023,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2003,12,22]],"date-time":"2003-12-22T00:00:00Z","timestamp":1072051200000},"content-version":"vor","delay-in-days":720,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2002,1]]},"abstract":"<jats:p><jats:bold>Objective\n\t\t\t\t\t<\/jats:bold> To investigate labour\u2010associated changes in: 1. the myometrial contractile response to arginine vasopressin compared with oxytocin <jats:italic>in vitro<\/jats:italic> 2. fetal production of arginine vasopressin and 3. myometrial vasopressin <jats:styled-content>V<jats:sub>1a<\/jats:sub><\/jats:styled-content> receptor mRNA.<\/jats:p><jats:p><jats:bold>Design\n\t\t\t\t\t<\/jats:bold> The contractile response to vasopressin (compared with oxytocin) was investigated in paired myometrial strips <jats:italic>in vitro<\/jats:italic>. Blood was taken from the umbilical artery and vein at delivery and arginine vasopressin measured by radio\u2010immunoassay. <jats:styled-content>V<jats:sub>1a<\/jats:sub><\/jats:styled-content> receptor mRNA was determined by <jats:italic>in situ<\/jats:italic> hybridisation.<\/jats:p><jats:p><jats:bold>Results\n\t\t\t\t\t<\/jats:bold> Myometrium was more sensitive to arginine vasopressin than oxytocin (<jats:styled-content><jats:italic>P<\/jats:italic> &lt;0.05 for frequency, amplitude and activity integral in paired strips<\/jats:styled-content>) after, but not before labour. There was a marked umbilical arteriovenous difference in arginine vasopressin concentration at delivery suggesting fetal production which was not influenced by labour. Myometrial vasopressin <jats:styled-content>V<jats:sub>1a<\/jats:sub><\/jats:styled-content> receptor mRNA was not increased after the onset of labour.<\/jats:p><jats:p><jats:bold>Conclusions\n\t\t\t\t\t<\/jats:bold> The human uterus is extremely sensitive to arginine vasopressin <jats:italic>in vitro<\/jats:italic>. Arginine vasopressin is produced by the fetus but fetal formation is not increased during labour.<\/jats:p>","DOI":"10.1111\/j.1471-0528.2002.01132.x","type":"journal-article","created":{"date-parts":[[2003,12,22]],"date-time":"2003-12-22T16:38:24Z","timestamp":1072111104000},"page":"57-62","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["The role of arginine vasopressin in human labour: functional studies, fetal production and localisation of V<sub>1a<\/sub> receptor mRNA"],"prefix":"10.1111","volume":"109","author":[{"given":"S.","family":"Thornton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.J.","family":"Baldwin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.A.","family":"Harris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Harding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.M.","family":"Davison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.H.","family":"Baylis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.M.","family":"Timmons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.C.","family":"Wathes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,12,22]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2000.104950"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2000.105816"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2000.95834"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1999.tb08112.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(89)90941-1"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(94)90415-4"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-64-6-1129"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114017"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1994.tb21768.x"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1600075"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0361-9230(91)90178-M"},{"key":"e_1_2_6_13_2","first-page":"37","article-title":"On the reproductive and developmental differences within the Brattleboro strain","volume":"48","author":"Boer GJ","year":"1998","journal-title":"Ann NY Acad Sci"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(79)80162-6"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/234352a0"},{"key":"e_1_2_6_16_2","first-page":"179","article-title":"Vasopressin concentration in cord blood: correlation with method of delivery and cord pH","volume":"60","author":"Parboosingh J","year":"1982","journal-title":"Obstet Gynecol"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(80)80206-X"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1993.tb15266.x"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-70-4-1142"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)05247-7"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1080\/15321818208056990"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1610143"},{"key":"e_1_2_6_23_2","doi-asserted-by":"crossref","first-page":"3304","DOI":"10.1016\/S0021-9258(17)41863-1","article-title":"Molecular cloning, sequencing, and functional expression of a cDNA: encoding the human V (1a) vasopressin receptor","volume":"269","author":"Thibonnier M","year":"1994","journal-title":"J Biol Chem"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1600021"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2001.110695"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1999.tb08188.x"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-70-4-1142"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(98)70027-4"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(84)90677-X"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1986.tb10289.x"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.0650411"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1988.tb12802.x"}],"container-title":["BJOG: An International Journal of Obstetrics &amp; Gynaecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1471-0528.2002.01132.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1471-0528.2002.01132.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T19:02:26Z","timestamp":1697569346000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/j.1471-0528.2002.01132.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,1]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2002,1]]}},"alternative-id":["10.1111\/j.1471-0528.2002.01132.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1471-0528.2002.01132.x","archive":["Portico"],"relation":{},"ISSN":["1470-0328","1471-0528"],"issn-type":[{"value":"1470-0328","type":"print"},{"value":"1471-0528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,1]]},"assertion":[{"value":"2003-12-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}