{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:13:58Z","timestamp":1792026838029,"version":"4.4.0"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2003,12,22]],"date-time":"2003-12-22T00:00:00Z","timestamp":1072051200000},"content-version":"vor","delay-in-days":720,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2002,1]]},"abstract":"<jats:p><jats:bold>Objective\n\t\t\t\t\t<\/jats:bold> To assess the effect of amnioinfusion during labour with meconium stained amniotic fluid on caesarean section rate and perinatal outcome.<\/jats:p><jats:p><jats:bold>Design\n\t\t\t\t\t<\/jats:bold> Prospective randomised controlled study.<\/jats:p><jats:p><jats:bold>Setting\n\t\t\t\t\t<\/jats:bold> A tertiary care teaching hospital in India.<\/jats:p><jats:p><jats:bold>Population\n\t\t\t\t\t<\/jats:bold> Women in labour at term with meconium stained amniotic fluid.<\/jats:p><jats:p><jats:bold>Methods\n\t\t\t\t\t<\/jats:bold> Two hundred women in labour with \u226537 weeks gestation, single cephalic presentation with moderate or thick meconium were randomised to control and amnioinfusion groups at a 1:1 ratio. Amnioinfusion was performed using 500mL of normal saline over a period of 30 minutes in a study group. The control group received routine care. Both groups had intermittent auscultation of fetal heart rate during labour.<\/jats:p><jats:p><jats:bold>Main outcome measures\n\t\t\t\t\t<\/jats:bold> The primary outcome measure was caesarean section rate. Secondary outcome measures were meconium aspiration syndrome, 1 minute and 5 minute apgar <jats:styled-content>&lt;7<\/jats:styled-content>, hypoxic ischaemic encephalopathy, neonatal intensive care unit admission, meconium at the level of vocal cords.<\/jats:p><jats:p><jats:bold>Results\n\t\t\t\t\t<\/jats:bold> The caesarean section rate in the amnioinfusion group was less than the control group (RR 0.47; 95% CI 0.24\u20130.93). Amnioinfusion was associated with a significant decrease in the incidence of meconium at the vocal cords (<jats:styled-content><jats:italic>P<\/jats:italic>= 0.001<\/jats:styled-content>); improvement in 1 minute apgar scores (<jats:styled-content><jats:italic>P<\/jats:italic> &lt;0.05<\/jats:styled-content>), respiratory distress (<jats:styled-content><jats:italic>P<\/jats:italic>= 0.002<\/jats:styled-content>) and fewer admissions to nursery compared with the controls. This sample size was inadequate to study the impact on meconium aspiration syndrome.<\/jats:p><jats:p><jats:bold>Conclusion\n\t\t\t\t\t<\/jats:bold> Amnioinfusion in an under resourced labour ward decreases caesarean section rates and fetal morbidity.<\/jats:p>","DOI":"10.1111\/j.1471-0528.2002.01140.x","type":"journal-article","created":{"date-parts":[[2003,12,22]],"date-time":"2003-12-22T16:38:24Z","timestamp":1072111104000},"page":"17-20","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Randomised trial of amnioinfusion during labour with meconium stained amniotic fluid"],"prefix":"10.1111","volume":"109","author":[{"given":"Asmita Muthal","family":"Rathorea","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruchira","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Ramji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reva","family":"Tripathi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,12,22]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(92)91856-6"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(85)90506-X"},{"key":"e_1_2_5_4_2","first-page":"647","article-title":"The prevention of meconium aspiration in labour using amnioinfusion","volume":"73","author":"Wenstrom KD","year":"1989","journal-title":"Obstet Gynecol"},{"key":"e_1_2_5_5_2","volume-title":"Cochrane Library Issue 1","author":"Hofmeyr GJ","year":"1999"},{"key":"e_1_2_5_6_2","first-page":"834","volume-title":"Neonatal Perinatal Medicine\u2014Diseases of the Fetus and Infant","author":"Fanaroff AA","year":"1992"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1976.00500100030012"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.6100.1451"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(91)90460-9"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1998.tb10091.x"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1998.tb10092.x"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.268.16.2276"},{"key":"e_1_2_5_13_2","first-page":"745","volume-title":"Holland & Brews Manual of Obstetrics","author":"Percival R","year":"1988"},{"key":"e_1_2_5_14_2","first-page":"494","volume-title":"Holland & Brews Manual of Obstetrics","author":"Percival R","year":"1988"},{"key":"e_1_2_5_15_2","first-page":"349","article-title":"Failure to prevent meconium aspiration syndrome","volume":"71","author":"Falciglia H","year":"1988","journal-title":"Obstet Gynecol"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.1997.tb02412.x"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(94)70296-9"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(89)90364-5"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.1996.tb02181.x"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.1993.tb02053.x"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1177\/004947559802800109"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(11)91641-X"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(94)90027-2"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(94)70061-3"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-994699"},{"key":"e_1_2_5_26_2","first-page":"383","article-title":"Effect of amnioinfusion on the incidence of postpartum endometritis in patients undergoing caesarean delivery","volume":"40","author":"Moen Michael D","year":"1995","journal-title":"J Reprod Med"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(90)91074-M"}],"container-title":["BJOG: An International Journal of Obstetrics &amp; 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