{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T19:51:24Z","timestamp":1725911484613},"reference-count":19,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2004,9,20]],"date-time":"2004-09-20T00:00:00Z","timestamp":1095638400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2004,10]]},"abstract":"<jats:p><jats:bold>Objective\u2003<\/jats:bold> To relate umbilical artery blood gas parameters to mortality among neonates with hypoxic\u2013ischaemic encephalopathy related to early onset seizures.<\/jats:p><jats:p><jats:bold>Design\u2003<\/jats:bold> Population cohort study.<\/jats:p><jats:p><jats:bold>Setting\u2003<\/jats:bold> British Columbia Women's Hospital.<\/jats:p><jats:p><jats:bold>Population\u2003<\/jats:bold> Forty\u2010seven infants at \u226532 weeks of gestation admitted to NICU with early onset seizures secondary to hypoxic\u2013ischaemic encephalopathy with umbilical artery blood gases done at delivery.<\/jats:p><jats:p><jats:bold>Methods\u2003<\/jats:bold> Patients were divided into two groups: (1) Infants with neonatal seizures who survived, and (2) infants with neonatal seizures who died related to hypoxic\u2013ischaemic encephalopathy complications. Comparison of umbilical artery pH, PO<jats:sub>2<\/jats:sub>, PCO<jats:sub>2<\/jats:sub>, base deficit was done between the two groups with Student's <jats:italic>t<\/jats:italic> tests.<\/jats:p><jats:p><jats:bold>Main outcome measures\u2003<\/jats:bold> Umbilical artery pH, PO<jats:sub>2<\/jats:sub>, PCO<jats:sub>2<\/jats:sub> and base deficit.<\/jats:p><jats:p><jats:bold>Results\u2003<\/jats:bold> The PO<jats:sub>2<\/jats:sub> was significantly higher in the group that expired (18.36 \u00b1 9.15 <jats:italic>vs<\/jats:italic> 12.33 \u00b1 7.51). There were no significant differences in any other blood gas parameters between the groups.<\/jats:p><jats:p><jats:bold>Conclusion\u2003<\/jats:bold> Neither the umbilical artery pH nor base deficit is predictive of neonatal death in infants with hypoxic\u2013ischaemic encephalopathy with seizures. The finding of a high PO<jats:sub>2<\/jats:sub> in neonates who died may indicate an inability of those infants to efficiently extract oxygen from blood.<\/jats:p>","DOI":"10.1111\/j.1471-0528.2004.00196.x","type":"journal-article","created":{"date-parts":[[2004,9,20]],"date-time":"2004-09-20T11:28:36Z","timestamp":1095679716000},"page":"1042-1045","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Umbilical artery blood gas parameters in neonates with early onset seizures who die"],"prefix":"10.1111","volume":"111","author":[{"given":"Keith P.","family":"Williams","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Avash","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,9,20]]},"reference":[{"issue":"24","key":"e_1_2_5_2_2","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/S0095-5108(18)30161-1","article-title":"Hypoxic\u2013ischemic brain injury in term newborn: neuropathology, clinical aspects, and neuroimaging","volume":"3","author":"Rivkin MJ","year":"1997","journal-title":"Clin Perinatol"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1976.00500100030012"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(97)70385-5"},{"key":"e_1_2_5_5_2","unstructured":"ACOG Committee.Opinion inappropriate use of the terms fetal distress and birth asphyxia. 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