{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T18:49:09Z","timestamp":1780339749855,"version":"3.54.1"},"reference-count":18,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2004,9,20]],"date-time":"2004-09-20T00:00:00Z","timestamp":1095638400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2004,12]]},"abstract":"<jats:p><jats:bold>Objective\u2003<\/jats:bold> To assess the effectiveness of clinical follow up after primary surgery for early stage cervical cancer.<\/jats:p><jats:p><jats:bold>Design\u2003<\/jats:bold> Retrospective analysis of clinical follow up after radical hysterectomy and node dissection for early stage cervical cancer.<\/jats:p><jats:p><jats:bold>Setting\u2003<\/jats:bold> Gynaecological Oncology Cancer Centre.<\/jats:p><jats:p><jats:bold>Sample\u2003<\/jats:bold> Two hundred and ninety\u2010one patients who underwent surgery for cervical cancer.<\/jats:p><jats:p><jats:bold>Methods\u2003<\/jats:bold> Follow up data were collected retrospectively from hand\u2010searched patients notes, as well as a computerised database (Information System for Clinical Organisation [ISCO]). The data were analysed using the SPSS for windows (SPSS, Chicago, Illinois) statistics package, using \u03c7<jats:sup>2<\/jats:sup>, Kaplan\u2013Meier life tables and Cox Linear regression analysis.<\/jats:p><jats:p><jats:bold>Main outcome measures\u2003<\/jats:bold> To determine whether routine follow up was useful for detecting early recurrent disease.<\/jats:p><jats:p><jats:bold>Results\u2003<\/jats:bold> Two hundred and ninety\u2010one patients treated by radical hysterectomy and node dissections were followed up. The cumulative five\u2010year survival for all cases in our series was 80% and 53\/291 patients (18.2%) were found to have recurrent disease. The median period from surgery to recurrence was 17.6 months (3.0\u201360.0). Seven patients with recurrence were detected at a routine follow up examination, and two out of seven of the patients were asymptomatic. Detection of the recurrence on routine follow up was not an independent prognostic factor for survival when compared with age, stage and whether the patient received post\u2010operative adjuvant therapy.<\/jats:p><jats:p><jats:bold>Conclusions\u2003<\/jats:bold> Routine follow up in patients following radical hysterectomy and node dissection for early stage cervical cancer is not a sensitive way of detecting recurrent disease, as a high proportion of patients were symptomatic at the time of detection. As there are other reasons for follow up, we propose alternative methods of structuring the programme.<\/jats:p>","DOI":"10.1111\/j.1471-0528.2004.00280.x","type":"journal-article","created":{"date-parts":[[2004,11,22]],"date-time":"2004-11-22T15:38:37Z","timestamp":1101137917000},"page":"1444-1448","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["The role of clinical follow up in early stage cervical cancer in South Wales"],"prefix":"10.1111","volume":"111","author":[{"given":"K.C.K.","family":"Lim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.E.J.","family":"Howells","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.S.","family":"Evans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,11,22]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1996.196"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1996.tb09600.x"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.2000.5860"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1994.1140"},{"issue":"4","key":"e_1_2_6_6_2","first-page":"422","article-title":"Recurrent cancer of the cervix following radical hysterectomy and pelvic node dissection","volume":"59","author":"Krebs HB","year":"1982","journal-title":"Obstet Gynecol"},{"issue":"1","key":"e_1_2_6_7_2","first-page":"6","article-title":"Diagnosis of recurrent cervical carcinoma after radical hysterectomy","volume":"71","author":"Larson DM","year":"1988","journal-title":"Obstet Gynecol"},{"issue":"1","key":"e_1_2_6_8_2","first-page":"106","article-title":"A comparison of symptomatology, physical examination, and vaginal cytology in the detection of recurrent cervical carcinoma after radical hysterectomy","volume":"76","author":"Soisson AP","year":"1990","journal-title":"Obstet Gynecol"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.1995.tb01986.x"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1997.tb10672.x"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1996.tb09843.x"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1997.tb10979.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1994.1282"},{"key":"e_1_2_6_14_2","first-page":"135","volume-title":"Improving outcomes in gynaecological cancer: the research evidence","author":"Eastwood A","year":"2001"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1438.2001.01042.x"},{"key":"e_1_2_6_16_2","first-page":"1161","volume-title":"Te Linde's Operative Gynaecology","author":"Thompson JD","year":"1992"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-8258(89)90549-0"},{"key":"e_1_2_6_18_2","first-page":"879","article-title":"Costs and benefits of routine follow\u2010up after curative treatment for endometrial cancer","volume":"157","author":"Agboola O","year":"1997","journal-title":"Can Med Assoc J"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.314.7075.174"}],"container-title":["BJOG: An International Journal of Obstetrics &amp; Gynaecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1471-0528.2004.00280.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1471-0528.2004.00280.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T00:27:21Z","timestamp":1697243241000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/j.1471-0528.2004.00280.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,11,22]]},"references-count":18,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2004,12]]}},"alternative-id":["10.1111\/j.1471-0528.2004.00280.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1471-0528.2004.00280.x","archive":["Portico"],"relation":{},"ISSN":["1470-0328","1471-0528"],"issn-type":[{"value":"1470-0328","type":"print"},{"value":"1471-0528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,11,22]]},"assertion":[{"value":"2004-11-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}