{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T20:16:42Z","timestamp":1771013802874,"version":"3.50.1"},"reference-count":11,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,9,13]],"date-time":"2004-09-13T00:00:00Z","timestamp":1095033600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2005,1]]},"abstract":"<jats:p><jats:bold>Objective\u2003<\/jats:bold> To examine whether a previous caesarean section increases the risk for complications in women undergoing a mid\u2010trimester pregnancy termination by labour induction.<\/jats:p><jats:p><jats:bold>Design\u2003<\/jats:bold> Retrospective analysis of case records between 1997 and 2002.<\/jats:p><jats:p><jats:bold>Setting\u2003<\/jats:bold> Fetal Medicine Unit of a large teaching hospital.<\/jats:p><jats:p><jats:bold>Population\u2003<\/jats:bold> One hundred and eight women with a previous caesarean section (study group) and 216 women without such a history (controls), who underwent a second trimester termination of pregnancy.<\/jats:p><jats:p><jats:bold>Methods\u2003<\/jats:bold> All the terminations were performed between 17 and 24 weeks of gestation by using 400 \u03bcg of oral administration of misoprostol in combination with 400 \u03bcg of intravaginal misoprostol. The same dose of intravaginal misoprostol was repeated every 6 hours for a maximum of five doses.<\/jats:p><jats:p><jats:bold>Main outcome measures<\/jats:bold> Severe haemorrhage requiring blood transfusion, post\u2010abortal infection, retained placenta and uterine rupture.<\/jats:p><jats:p><jats:bold>Result\u2003<\/jats:bold> Complications occurred in 16 out of 108 women of the study group (15%) and in 26 out of 216 of the controls (12%), with only one ruptured uterus in the control group.<\/jats:p><jats:p><jats:bold>Conclusion\u2003<\/jats:bold> We found no evidence that a previous caesarean delivery affects the incidence of complications when women with such a history undergo a mid\u2010trimester pregnancy termination with misoprostol.<\/jats:p>","DOI":"10.1111\/j.1471-0528.2004.00285.x","type":"journal-article","created":{"date-parts":[[2004,12,14]],"date-time":"2004-12-14T09:34:54Z","timestamp":1103016894000},"page":"97-99","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":67,"title":["Misoprostol for second trimester pregnancy termination in women with prior caesarean section"],"prefix":"10.1111","volume":"112","author":[{"given":"George J.","family":"Daskalakis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Spyros A.","family":"Mesogitis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolaos E.","family":"Papantoniou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George G.","family":"Moulopoulos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angeliki A.","family":"Papapanagiotou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aris J.","family":"Antsaklis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,9,13]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1093\/oxfordjournals.humrep.a137927","article-title":"The abortifacient effect of misoprostol in the second trimester. A randomized comparison with gemeprost in patients pre\u2010treated with mifepristone (RU 486)","volume":"8","author":"El\u2010Refaey H","year":"1993","journal-title":"Hum Reprod"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(97)00419-5"},{"key":"e_1_2_5_4_2","first-page":"401","article-title":"Deaths from second trimester abortion by dilatation and evacuation: causes, prevention, facilities","volume":"58","author":"Cates WJ","year":"1981","journal-title":"Obstet Gynecol"},{"key":"e_1_2_5_5_2","first-page":"461","article-title":"Fatal haemorrhage from legal abortion in the United States","volume":"157","author":"Grimes DA","year":"1983","journal-title":"Surg Obstet Gynecol"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(80)90010-1"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(85)90582-4"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1159\/000292602"},{"key":"e_1_2_5_9_2","first-page":"912","article-title":"Uterine rupture complicating midtrimester abortion: a report of two cases","volume":"34","author":"Hagay ZJ","year":"1989","journal-title":"J Reprod Med"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016348409155513"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(91)90094-8"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1990.tb02484.x"}],"container-title":["BJOG: An International Journal of Obstetrics &amp; Gynaecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1471-0528.2004.00285.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1471-0528.2004.00285.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T03:50:08Z","timestamp":1696996208000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/j.1471-0528.2004.00285.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,9,13]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,1]]}},"alternative-id":["10.1111\/j.1471-0528.2004.00285.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1471-0528.2004.00285.x","archive":["Portico"],"relation":{},"ISSN":["1470-0328","1471-0528"],"issn-type":[{"value":"1470-0328","type":"print"},{"value":"1471-0528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,9,13]]},"assertion":[{"value":"2004-09-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}