{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T15:43:29Z","timestamp":1788536609900,"version":"build-2803163510"},"reference-count":6,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2004,12,17]],"date-time":"2004-12-17T00:00:00Z","timestamp":1103241600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2005,6]]},"abstract":"<jats:p><jats:bold>Objective\u2003<\/jats:bold> Angiotensin II type 1 receptor antagonists (ARA). Interacted with the renin\u2013angiotensin system, and the present study was undertaken to examine their fetal and neonatal toxicity when taken by the mother during pregnancy.<\/jats:p><jats:p><jats:bold>Design\u2003<\/jats:bold> Prospective follow up of pregnant women exposed to an ARA during early pregnancy.<\/jats:p><jats:p><jats:bold>Setting\u2003<\/jats:bold> The present study was conducted in the departments of Paedriatric Pharmacology of the University hospital Robert Debr\u00e9 in Paris, France.<\/jats:p><jats:p><jats:bold>Population\u2003<\/jats:bold> Ten women exposed to an ARA during early pregnancy.<\/jats:p><jats:p><jats:bold>Methods\u2003<\/jats:bold> Prospective follow up.<\/jats:p><jats:p><jats:bold>Main outcome measure\u2003<\/jats:bold> Fetal ultrasonography and outcome of pregnancy.<\/jats:p><jats:p><jats:bold>Results\u2003<\/jats:bold> Prenatal ultrasonography showed abnormal features in five cases (oligoamnios related to fetal tabular dysgenesis, fetal dysmorphia and renal abnormalities). Outcome of pregnancy was as follows: three induced abortions, two stillbirths (twin pregnancy), one neonate presenting with dysmorphia and renal disease and five neonates with an uneventful development.<\/jats:p><jats:p><jats:bold>Conclusion\u2003<\/jats:bold> Women of reproductive age should be advised of the possible hazards of ARA and treatment should be stopped as soon as pregnany has been documented.<\/jats:p>","DOI":"10.1111\/j.1471-0528.2004.00525.x","type":"journal-article","created":{"date-parts":[[2006,9,21]],"date-time":"2006-09-21T09:35:22Z","timestamp":1158831322000},"page":"710-712","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Developmental toxicity of the angiotensin II type 1 receptor antagonists during human pregnancy: a report of 10 cases"],"prefix":"10.1111","volume":"112","author":[{"given":"Raphael","family":"Serreau","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Luton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Alice","family":"Macher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne\u2010Lise","family":"Delezoide","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Garel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyne","family":"Jacqz\u2010Aigrain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,4,20]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04759-0"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)05426-5"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0146-0005(97)80055-9"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420510604"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64767-0"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.3109\/15513818509026897"}],"container-title":["BJOG: An International Journal of Obstetrics &amp; Gynaecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1471-0528.2004.00525.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1471-0528.2004.00525.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T20:22:19Z","timestamp":1696969339000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/j.1471-0528.2004.00525.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,4,20]]},"references-count":6,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2005,6]]}},"alternative-id":["10.1111\/j.1471-0528.2004.00525.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1471-0528.2004.00525.x","archive":["Portico"],"relation":{},"ISSN":["1470-0328","1471-0528"],"issn-type":[{"value":"1470-0328","type":"print"},{"value":"1471-0528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,4,20]]},"assertion":[{"value":"2005-04-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}