{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:05:27Z","timestamp":1791158727904,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T00:00:00Z","timestamp":1106870400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2005,7]]},"abstract":"<jats:p><jats:bold>Objective\u2003<\/jats:bold> To establish the risk of serious complications from severe pre\u2010eclampsia and eclampsia in a region using a common guideline for the management of these conditions.<\/jats:p><jats:p><jats:bold>Design\u2003<\/jats:bold> A five\u2010year prospective study.<\/jats:p><jats:p><jats:bold>Setting\u2003<\/jats:bold> Sixteen maternity units in Yorkshire.<\/jats:p><jats:p><jats:bold>Population\u2003<\/jats:bold> All women managed with severe pre\u2010eclampsia and eclampsia.<\/jats:p><jats:p><jats:bold>Methods\u2003<\/jats:bold> A common guideline was developed for the management of women with these conditions. A network of midwives prospectively collected outcome data.<\/jats:p><jats:p><jats:bold>Main outcome measure\u2003<\/jats:bold> Incidence of the conditions and serious complication rates.<\/jats:p><jats:p><jats:bold>Results\u2003<\/jats:bold> A total of 210,631 women delivered in the 16 units between 1 January 1999 and 31 December 2003. One thousand eighty\u2010seven women were diagnosed with severe pre\u2010eclampsia or eclampsia (5.2\/1000). One hundred and fifty\u2010one women had serious complications including 82 women (39\/10,000) having eclamptic seizures and 49 women (23\/10,000) requiring ICU admission. There were no maternal deaths but 54 out of 1145 babies died before discharge, giving a mortality rate of 47.2\/1000. Of the 82 cases of eclampsia, 45 occurred antenatally (55%), 18 before admission to the maternity unit. Eleven cases occurred in labour (13%), including 1 during a caesarean section, and 26 cases occurred following delivery (32%). Twenty\u2010five women developed pulmonary oedema (2.3% of cases) and six women required renal dialysis (0.55% of cases). One hundred and sixty\u2010five (15%) required no antihypertensive therapy and 489 (53%) of the remainder required only oral therapy. Two hundred and one (18.5%) required more than one drug.<\/jats:p><jats:p><jats:bold>Conclusion\u2003<\/jats:bold> A regional guideline for severe pre\u2010eclampsia and eclampsia can be developed and implemented. Its use may contribute to a low rate of serious complications.<\/jats:p>","DOI":"10.1111\/j.1471-0528.2005.00565.x","type":"journal-article","created":{"date-parts":[[2005,6,15]],"date-time":"2005-06-15T12:44:48Z","timestamp":1118839488000},"page":"875-880","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":128,"title":["Outcomes of severe pre\u2010eclampsia\/eclampsia in Yorkshire 1999\/2003"],"prefix":"10.1111","volume":"112","author":[{"given":"D.J.","family":"Tuffnell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Jankowicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.W.","family":"Lindow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Lyons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.C.","family":"Mason","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.F.","family":"Russell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.J.","family":"Walker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"On behalf of the Yorkshire Obstetric Critical Care Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,5,17]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)08778-0"},{"key":"e_1_2_7_3_2","volume-title":"Why Mothers Die. 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