{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:03:31Z","timestamp":1761487411951},"reference-count":27,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2005,1,27]],"date-time":"2005-01-27T00:00:00Z","timestamp":1106784000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2005,7]]},"abstract":"<jats:p><jats:bold>Objective\u2003<\/jats:bold> To examine how the subsequent childbearing of HIV\u2010infected mothers enrolled in the European Collaborative Study (ECS) has changed over time and identify factors predictive of further childbearing.<\/jats:p><jats:p><jats:bold>Design\u2003<\/jats:bold> Prospective cohort study.<\/jats:p><jats:p><jats:bold>Setting\u2003<\/jats:bold> Centres in nine European countries included in the ECS, enrolled between end 1986 and November 2003.<\/jats:p><jats:p><jats:bold>Population\u2003<\/jats:bold> HIV\u2010infected women (3911): 3693 with only one and 218 with subsequent live births.<\/jats:p><jats:p><jats:bold>Methods\u2003<\/jats:bold> Univariable and multivariable logistic regression analyses to obtain odds ratios (OR) and 95% confidence intervals (CI). Kaplan\u2013Meier (KM) analyses to estimate cumulative proportions of women having a subsequent live birth.<\/jats:p><jats:p><jats:bold>Main outcome measures\u2003<\/jats:bold> Subsequent live birth.<\/jats:p><jats:p><jats:bold>Results\u2003<\/jats:bold> In multivariable analysis adjusting for time period, ethnicity, maternal age and parity, black women were more likely [adjusted odds ratio (AOR) 2.45; 95% CI, 1.75\u20133.43], and women &gt;30 years less likely (AOR 0.54, 0.37\u20130.80), to have a subsequent live birth. Time to subsequent live birth significantly shortened over time, with an estimated 2% of women having a subsequent live birth within 24 months of enrolment pre\u20101989 versus 14% in 2000\u20132003 (<jats:italic>P<\/jats:italic> &lt; 0.001). Estimated time to subsequent live birth was shorter for black than for white women (<jats:italic>P<\/jats:italic> &lt; 0.001).<\/jats:p><jats:p><jats:bold>Conclusions\u2003<\/jats:bold> The likelihood of subsequent live births substantially increased after 1995 and birth intervals were shorter in women on HAART and among black women. Numbers are currently too small to address the issue of advantages and disadvantages in the management of subsequent deliveries.<\/jats:p>","DOI":"10.1111\/j.1471-0528.2005.00569.x","type":"journal-article","created":{"date-parts":[[2005,6,15]],"date-time":"2005-06-15T12:44:48Z","timestamp":1118839488000},"page":"881-888","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Increasing likelihood of further live births in HIV\u2010infected women in recent years"],"prefix":"10.1111","volume":"112","author":[{"name":"European Collaborative Study","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,5,17]]},"reference":[{"key":"e_1_2_6_2_2","unstructured":"WHO\u2010EC Collaborating Centre on AIDS.HIV\/AIDS Surveillance in Europe end year report 2002 no. 68 2003. 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High risk behaviour and fertility desires among heterosexual HIV\u2010positive patients with a serodiscordant partner\u2014two challenging issues","volume":"133","author":"Panozzo L","year":"2003","journal-title":"Swiss Med Wkly"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000117083.33239.b5"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200401230-00018"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/00042560-199808150-00010"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0277-9536(94)00280-7"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1067\/S0002-9378(03)00467-8"},{"key":"e_1_2_6_24_2","first-page":"425","article-title":"Antenatal and neonatal antiretroviral therapy in HIV\u2010infected women and their infants: a review of safety issues","volume":"7","author":"Thorne C","year":"2003","journal-title":"Dev Perinat Med"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)08084-2"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199904013401301"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1086\/318530"},{"key":"e_1_2_6_28_2","unstructured":"European Collaborative Study.Mother\u2010to\u2010child transmission of HIV\u20101 in the HAART era.Clin Infect Dis. 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