{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:58:34Z","timestamp":1791237514141,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,3,27]],"date-time":"2006-03-27T00:00:00Z","timestamp":1143417600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2006,5]]},"abstract":"<jats:p>\n                    <jats:bold>Objective\u2002<\/jats:bold>\n                    To evaluate placental morphology in pregnancies complicated by early\u2010 and late\u2010onset pre\u2010eclampsia (PET) with and without fetal growth restriction (FGR) using stereological techniques.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Design\u2002<\/jats:bold>\n                    A total of 69 pregnant women were studied. Twenty women had pregnancies complicated by PET, 17 by FGR and 16 by both PET and FUR; the remaining 16 were from gestational\u2010age\u2010matched controls. Each group was further classified into early onset (&lt;34 weeks) and late onsets (&gt;34 weeks) based on gestational ages.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Setting\u2002<\/jats:bold>\n                    NPIMR at Northwick Park and St Marks Hospital.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Population\u2002<\/jats:bold>\n                    placentae from pregnant women.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods\u2002<\/jats:bold>\n                    Formalin\u2010fixed, wax\u2010embedded sections stained with anti\u2010CD34 antibodies and counterstained with haematoxylin.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Main outcome measures\u2002<\/jats:bold>\n                    Volumes, surface areas, lengths, diameters and shape factors of the villous tissues and fetal vasculature in the intermediate and terminal villi of all the groups studied.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results\u2002<\/jats:bold>\n                    Terminal villi volume and surface area were compromised in early\u2010onset PET cases, late\u2010onset PET had no impact on peripheral villi or vasculature features. The morphology of the vascular and villous subcomponents in the intermediate and terminal villi was significantly influenced by late\u2010onset FGR, whereas early\u2010onset FGR caused a reduction in placental weight. Length estimates were not influenced by PET, FGR or age of onset. Intermediate arteriole shape factor was significantly reduced in late\u2010onset FGR.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions\u2002<\/jats:bold>\n                    Isolated early\u2010onset PET was associated with abnormal placental morphology, but placentas from late\u2010onset PET were morphologically similar to placentas from gestational\u2010age\u2010matched controls, confirming the existence of two subsets of this condition and supporting the hypothesis that late\u2010onset PET is a maternal disorder and not a placental disease.\n                  <\/jats:p>","DOI":"10.1111\/j.1471-0528.2006.00882.x","type":"journal-article","created":{"date-parts":[[2006,3,27]],"date-time":"2006-03-27T17:56:35Z","timestamp":1143482195000},"page":"580-589","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":318,"title":["Maternal medicine: Morphometric placental villous and 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