{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T16:04:58Z","timestamp":1791561898497,"version":"4.3.4"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,3,17]],"date-time":"2006-03-17T00:00:00Z","timestamp":1142553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2006,4]]},"abstract":"<jats:p><jats:bold>Background\u2002<\/jats:bold> Features of the metabolic syndrome\u2014maternal obesity, diabetes mellitus and chronic hypertension\u2014are risk factors for pre\u2010eclampsia.<\/jats:p><jats:p><jats:bold>Objectives\u2002<\/jats:bold> To determine the risk of pre\u2010eclampsia in the presence of maternal hypertriglyceridemia, another major element of the metabolic syndrome.<\/jats:p><jats:p><jats:bold>Search strategy\u2002<\/jats:bold> Two investigators independently searched PubMed and Embase databases from 1980 to December 2004 for relevant studies. The terms preeclampsia, eclampsia, pregnancy\u2010induced hypertension or toxemia were combined with dyslipidemia, hyperlipidemia, hypertriglyceridemia, lipids, cholesterol, triglycerides (TG) or lipoprotein.<\/jats:p><jats:p><jats:bold>Selection criteria\u2002<\/jats:bold> We included case\u2013control and cohort studies published in English that included at least 20 women with pre\u2010eclampsia and that sampled serum or plasma TG at any time before, during or after pregnancy.<\/jats:p><jats:p><jats:bold>Data collection and analysis\u2002<\/jats:bold> Mean maternal TG concentrations were compared between cases and controls within each study. The odds ratio of pre\u2010eclampsia was calculated by comparing the risk of pre\u2010eclampsia among women in each higher TG concentration category with that in the lowest reference category.<\/jats:p><jats:p><jats:bold>Main results\u2002<\/jats:bold> A total of 19 case\u2013control and 3 prospective cohort studies were included. In 14 studies, the mean TG concentration was significantly higher among pre\u2010eclamptic cases than among unaffected controls; in seven other studies, there was a nonsignificant trend in the same direction. The risk of pre\u2010eclampsia typically doubled with each increasing TG category. In the four studies that adjusted for potential confounders, such as maternal age, parity and body mass index, there was about a four\u2010fold higher risk of pre\u2010eclampsia in the highest relative to the lowest TG category.<\/jats:p><jats:p><jats:bold>Author's conclusions\u2002<\/jats:bold> There exists a consistent positive association between elevated maternal TG and the risk of pre\u2010eclampsia. Given that maternal hypertriglyceridemia is a common feature of the metabolic syndrome, interventional studies are needed to determine whether pre\u2010pregnancy weight reduction and dietary modification can lower the risk of pre\u2010eclampsia.<\/jats:p>","DOI":"10.1111\/j.1471-0528.2006.00889.x","type":"journal-article","created":{"date-parts":[[2006,3,17]],"date-time":"2006-03-17T15:44:01Z","timestamp":1142610241000},"page":"379-386","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":135,"title":["Brief overview of maternal triglycerides as a risk factor for pre\u2010eclampsia"],"prefix":"10.1111","volume":"113","author":[{"given":"JG","family":"Ray","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Diamond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CM","family":"Bell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,5,5]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.157.8.821"},{"key":"e_1_2_6_3_2","first-page":"434","article-title":"Plasma lipids and lipoprotein reference values, and the prevalence of dyslipoproteinemia in Canadian adults. Canadian Heart Health Surveys Research Group","volume":"15","author":"MacLean DR","year":"1999","journal-title":"Can J Cardiol"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.3.356"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.14.1728"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.EDE.0000059921.71494.D1"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwg273"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a009400"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(94)90276-3"},{"key":"e_1_2_6_10_2","volume-title":"Elementary Survey Sampling","author":"Scheaffer RL","year":"1996"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(81)90071-1"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1042\/CS19980387"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0412.1999.780304.x"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(96)02613-9"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016349609055024"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1995.tb11355.x"},{"key":"e_1_2_6_17_2","first-page":"43","article-title":"Lipid profile in women with preeclampsia: relationship between plasma triglyceride levels and severity of preeclampsia","volume":"6","author":"Mikhail MS","year":"1995","journal-title":"J Assoc Acad Minor Phys"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2001.00247.x"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-7061(03)00897-5"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0026-0495(97)90088-3"},{"key":"e_1_2_6_21_2","first-page":"192","article-title":"Study of serum lipid and lipoprotein in pre\u2010eclampsia with special reference to parity","volume":"44","author":"Khaliq F","year":"2000","journal-title":"Indian J Physiol Pharmacol"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-0528.2003.02349.x"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjhyper.2004.03.666"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0026-0495(98)90337-7"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(98)70033-X"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1159\/000010041"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7292(99)00161-7"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.3109\/10641959909016196"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(03)00240-9"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0412.2004.00513.x"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2004.04.035"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0001-6349.2004.00539.x"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.82.8.2483"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.38.3.718"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)70804-7"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2004.10.003"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-005-0080-6"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-200007000-00012"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(99)70259-0"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1016250"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-199917090-00011"},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0965539504001287"},{"key":"e_1_2_6_43_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.292.12.1440"}],"container-title":["BJOG: An International Journal of Obstetrics &amp; Gynaecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1471-0528.2006.00889.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1471-0528.2006.00889.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T09:57:33Z","timestamp":1697018253000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/j.1471-0528.2006.00889.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,4]]},"references-count":42,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,4]]}},"alternative-id":["10.1111\/j.1471-0528.2006.00889.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1471-0528.2006.00889.x","archive":["Portico"],"relation":{},"ISSN":["1470-0328","1471-0528"],"issn-type":[{"value":"1470-0328","type":"print"},{"value":"1471-0528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,4]]},"assertion":[{"value":"2006-05-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}