{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T13:54:52Z","timestamp":1791640492315,"version":"4.3.4"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,3,17]],"date-time":"2006-03-17T00:00:00Z","timestamp":1142553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2006,4]]},"abstract":"<jats:p><jats:bold>Background\u2002<\/jats:bold> Pre\u2010eclampsia is one of the largest causes of maternal and fetal mortality and morbidity. Hyperuricemia is often associated with pre\u2010eclampsia.<\/jats:p><jats:p><jats:bold>Objective\u2002<\/jats:bold> To determine the accuracy with which serum uric acid predicts maternal and fetal complications in women with pre\u2010eclampsia.<\/jats:p><jats:p><jats:bold>Study design\u2002<\/jats:bold> Systematic quantitative review of test accuracy studies.<\/jats:p><jats:p><jats:bold>Search strategy\u2002<\/jats:bold> We conducted electronic searches in MEDLINE (1951\u20132004), EMBASE (1980\u20132004), the Cochrane Library (2004:4) and the MEDION database to identify relevant articles. A hand\u2010search of selected specialist journals and reference lists of articles obtained was then carried out. There were no language restrictions for any of these searches.<\/jats:p><jats:p><jats:bold>Selection criteria\u2002<\/jats:bold> Two reviewers independently selected the articles in which the accuracy of serum uric acid was evaluated to predict maternal and fetal complications of pre\u2010eclampsia.<\/jats:p><jats:p><jats:bold>Data collection and analysis\u2002<\/jats:bold> Data were extracted on study characteristics, quality and accuracy to construct 2 \u00d7 2 tables with maternal and fetal complications as reference standard. Summary likelihood ratios for positive (LR+) and negative LR(\u2212) test results are generated for various threshold levels of uric acid.<\/jats:p><jats:p><jats:bold>Main results\u2002<\/jats:bold> There were 18 primary articles that met the selection criteria, including a total of 3913 women and forty\u2010one 2 \u00d7 2 tables. In women with pre\u2010eclampsia, a positive test result of uric acid greater than or equal to a 350\u2010\u03bcmol\/l threshold predicted eclampsia with a pooled likelihood ratio (LR) of 2.1 (95% CI 1.4\u20133.5), while a negative test result had a pooled LR of 0.38 (95% CI 0.18\u20130.81). For severe hypertension as the outcome measure, the LRs were 1.7 (95% CI 1.3\u20132.2) and 0.49 (95% CI 0.38\u20130.64) for positive and negative test results, respectively, and for caesarean section the LRs were 2.4 (95% CI 1.3\u20134.7) and 0.39 (95% CI 0.20\u20130.76). For stillbirths and neonatal deaths the respective LRs were 1.5 (95% CI 0.91\u20132.6) and 0.51 (95% CI 0.20\u20131.3). For the prediction of small\u2010for\u2010gestational\u2010age fetus, the pooled LRs were 1.3 (95% CI 1.1\u20131.7) and 0.60 (95% CI 0.43\u20130.83) for positive and negative results, respectively.<\/jats:p><jats:p><jats:bold>Author's conclusion\u2002<\/jats:bold> Serum uric acid is a poor predictor of maternal and fetal complications in women with pre\u2010eclampsia.<\/jats:p>","DOI":"10.1111\/j.1471-0528.2006.00908.x","type":"journal-article","created":{"date-parts":[[2006,3,17]],"date-time":"2006-03-17T15:44:01Z","timestamp":1142610241000},"page":"369-378","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":167,"title":["Accuracy of serum uric acid in predicting complications of pre\u2010eclampsia: a systematic review"],"prefix":"10.1111","volume":"113","author":[{"given":"S","family":"Thangaratinam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KMK","family":"Ismail","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Sharp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Coomarasamy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KS","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,5,5]]},"reference":[{"key":"e_1_2_8_2_2","unstructured":"HMSO.Report on Confidential Enquiries into Maternal Deaths in the United Kingdom. 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