{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T11:11:42Z","timestamp":1787224302488,"version":"build-2736575974"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,5,2]],"date-time":"2006-05-02T00:00:00Z","timestamp":1146528000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2006,6]]},"abstract":"<jats:p><jats:bold>Objective\u2002<\/jats:bold> To analyse the fertility rates, complications and recurrences in a group of women who have undergone radical vaginal trachelectomy and pelvic lymphadenectomy for early\u2010stage cervical cancer.<\/jats:p><jats:p><jats:bold>Design\u2002<\/jats:bold> An observational series.<\/jats:p><jats:p><jats:bold>Setting\u2002<\/jats:bold> A Gynaecological Oncology Centre.<\/jats:p><jats:p><jats:bold>Population\u2002<\/jats:bold> One hundred and twenty\u2010three consecutive women who underwent radical vaginal trachelectomy and pelvic lymphadenectomy for early\u2010stage cervical cancer.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Data were collected prospectively.<\/jats:p><jats:p><jats:bold>Main outcome measures\u2002<\/jats:bold> Complications, recurrences, pregnancies and live births are presented as percentages of the total population. Fertility is presented as a 5\u2010year cumulative rate, with women attempting to conceive as the denominator.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> A total of 123 women were followed up for an average of 45 months. Eleven (8.9%) had completion treatment (two radical hysterectomies and nine chemoradiotherapy) at the time of initial treatment. There were three recurrences (2.7%) among the women who did not have completion treatment and two (18.2%) in those who did. There were 6 perioperative and 26 postoperative complications. Sixty\u2010three women attempted pregnancy. There were 55 pregnancies in 26 women and 28 live births in 19. Three women had continuing pregnancies. The 5\u2010year cumulative pregnancy rate among women trying to conceive was 52.8%. All but two women were delivered by classical caesarean section and seven (25.0%) babies were born at 31 + 6 weeks or less.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> For selected women with early\u2010stage cervical cancer, radical vaginal trachelectomy and pelvic lymphadenectomy are fertility\u2010sparing options, with a low incidence of recurrence and acceptable cumulative conception rates. Complications are few, although there is a high premature labour and miscarriage rate among pregnant women.<\/jats:p>","DOI":"10.1111\/j.1471-0528.2006.00936.x","type":"journal-article","created":{"date-parts":[[2006,5,2]],"date-time":"2006-05-02T17:59:50Z","timestamp":1146592790000},"page":"719-724","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":179,"title":["Radical vaginal trachelectomy as a fertility\u2010sparing procedure in women with early\u2010stage cervical cancer\u2014cumulative pregnancy rate in a series of 123 women"],"prefix":"10.1111","volume":"113","author":[{"given":"JH","family":"Shepherd","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Spencer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Herod","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TEJ","family":"Ind","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,5,2]]},"reference":[{"key":"e_1_2_5_2_2","unstructured":"Department of Health.Cervical Screening Programme England:20032004. 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