{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T07:55:50Z","timestamp":1776498950509,"version":"3.51.2"},"reference-count":11,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2006,6,22]],"date-time":"2006-06-22T00:00:00Z","timestamp":1150934400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:p>\n                    <jats:bold>Objective\u2002<\/jats:bold>\n                    To compare the cost\u2010effectiveness of levonorgestrel intrauterine system (LNG\u2010IUS) (Mirena\n                    <jats:sup>\u00ae<\/jats:sup>\n                    ; Schering Co., Turku, Finland) and thermal balloon ablation (Thermachoice\u2122; Gynecare Inc., Menlo Park, CA, USA) for the treatment of heavy menstrual bleeding.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Design\u2002<\/jats:bold>\n                    An open, pragmatic, prospective randomised trial.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Setting\u2002<\/jats:bold>\n                    A menstrual disorders clinic at National Women\u2019s Hospital, Auckland, New Zealand.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Population\u2002<\/jats:bold>\n                    Seventy\u2010nine women with self\u2010defined heavy menstrual bleeding randomised to the LNG\u2010IUS (40 women) or the thermal balloon ablation (39 women).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods\u2002<\/jats:bold>\n                    Decision tree modelling using primary source data was used to identify the incremental cost\u2010effectiveness of the two treatments.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Main outcome measures\u2002<\/jats:bold>\n                    Direct and indirect costs of medical treatment, including treatment costs, subsequent medical procedures, lost income and medical treatment for failed procedures. The change in quality of life as assessed by the Short Form\u201036 (SF\u201036) measured between time of treatment and 24 months was the primary outcome measure. Economic modelling examined the expected cost and outcome for a woman entering each treatment. Sensitivity analysis explored the robustness of the results.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results\u2002<\/jats:bold>\n                    The expected cost of treatment was $NZ1241 ($US869) for the LNG\u2010IUS and $NZ2418 ($US1693) for the thermal balloon ablation. The LNG\u2010IUS was associated with an increase of 15 points on the SF\u201036 scale, compared with 12 points for the thermal balloon ablation. Sensitivity analysis indicates that the results are robust to a 25% decrease in the price of the primary cost drivers and to variations in the rates of failed treatment between the conditions.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion\u2002<\/jats:bold>\n                    The LNG\u2010IUS would appear to be cost\u2010effective when compared with the thermal balloon ablation for treatment of heavy menstrual bleeding.\n                  <\/jats:p>","DOI":"10.1111\/j.1471-0528.2006.00944.x","type":"journal-article","created":{"date-parts":[[2006,6,22]],"date-time":"2006-06-22T12:58:29Z","timestamp":1150981109000},"page":"797-803","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Cost\u2010effectiveness analysis of levonorgestrel intrauterine system and thermal balloon ablation for heavy menstrual bleeding"],"prefix":"10.1111","volume":"113","author":[{"given":"PM","family":"Brown","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CM","family":"Farquhar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Lethaby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LC","family":"Sadler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"NP","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,6,22]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1997.tb10998.x"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.0962-1091.2002.00479.x"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1159\/000060290"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2006.00863.x"},{"key":"e_1_2_5_6_2","unstructured":"CBG Research.National GP Fee Survey.2001[www.moh.govt.nz\/moh.nsf\/0\/1BF9A9B04AA23B8ACC256EF4000D3A8A\/$File\/FeeSurveyReportCBG.pdf]. Accessed 12 June 2004."},{"key":"e_1_2_5_7_2","unstructured":"Statistics New Zealand.2001census of population and dwellings\u2014work education and income tables. [www.stats.govt.nz\/census\/work\u2010education\u2010income\u2010tables.htm]. Accessed 12 June 2004."},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1991.tb13484.x"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-0528.2002.01224.x"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh319"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.3310\/hta8030"},{"key":"e_1_2_5_12_2","volume-title":"The Cochrane Library","author":"Lethaby A","year":"2004"}],"container-title":["BJOG: An International Journal of Obstetrics &amp; Gynaecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1471-0528.2006.00944.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1471-0528.2006.00944.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T05:29:24Z","timestamp":1697002164000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/j.1471-0528.2006.00944.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,6,22]]},"references-count":11,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2006,7]]}},"alternative-id":["10.1111\/j.1471-0528.2006.00944.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1471-0528.2006.00944.x","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.14723.472239","asserted-by":"object"}]},"ISSN":["1470-0328","1471-0528"],"issn-type":[{"value":"1470-0328","type":"print"},{"value":"1471-0528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,6,22]]},"assertion":[{"value":"2006-06-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}