{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T18:14:46Z","timestamp":1788459286599,"version":"build-2803163510"},"reference-count":38,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2006,5,19]],"date-time":"2006-05-19T00:00:00Z","timestamp":1147996800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:p><jats:bold>Objective\u2002<\/jats:bold> To establish whether metformin has a significant action in reducing visceral fat and improving other metabolic parameters in women with polycystic ovary syndrome (PCOS).<\/jats:p><jats:p><jats:bold>Design\u2002<\/jats:bold> Randomised, double\u2010blind, placebo\u2010controlled trial.<\/jats:p><jats:p><jats:bold>Setting\u2002<\/jats:bold> Reproductive medicine clinic.<\/jats:p><jats:p><jats:bold>Population\u2002<\/jats:bold> Forty women with anovulatory PCOS.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Participants were randomised into receiving metformin 500 mg three times a day or placebo for 3 months.<\/jats:p><jats:p><jats:bold>Main outcome measures\u2002<\/jats:bold> Fat distribution was measured by computed tomography scan. Secondary outcome measures included serum indices of the metabolic syndrome and evidence of ovulation.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> We found no significant differences in any of the measures of fat distribution between the placebo and metformin groups. The metformin group had significantly lower total cholesterol (<jats:italic>P<\/jats:italic>= 0.02), low\u2010density lipoprotein cholesterol (<jats:italic>P<\/jats:italic>= 0.02) and cholesterol:high\u2010density lipoprotein cholesterol ratio (<jats:italic>P<\/jats:italic>= 0.05), but there was no statistically significant treatment effect on androgens, insulin, insulin resistance, triglycerides, ovulation or pregnancy.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Metformin has no clinically significant effect in reducing visceral fat mass, although it does have a beneficial effect on lipids. This trial lends support to the growing evidence that metformin is not a weight loss drug. 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