{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T13:40:21Z","timestamp":1773236421264,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2006,6,22]],"date-time":"2006-06-22T00:00:00Z","timestamp":1150934400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:p><jats:bold>Objective\u2002<\/jats:bold> To evaluate predictive factors for respiratory depression at birth in infants \u226537 weeks.<\/jats:p><jats:p><jats:bold>Design\u2002<\/jats:bold> A population\u2010based cohort study of respiratory depression at birth at term and post\u2010term.<\/jats:p><jats:p><jats:bold>Setting\u2002<\/jats:bold> Nova Scotia, Canada.<\/jats:p><jats:p><jats:bold>Population\u2002<\/jats:bold> All 126 604 nonanomalous, singleton deliveries \u226537 weeks in cephalic presentation from 1988\u20132002.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> An analysis of maternal, antenatal, intrapartum, and neonatal factors associated with respiratory depression at birth \u226537 weeks.<\/jats:p><jats:p><jats:bold>Main outcome measures\u2002<\/jats:bold> A composite outcome of delay in initiating and maintaining respiration after birth, 5\u2010minute Apgar score \u2264 3, or neonatal seizures due to hypoxic\u2013ischaemic encephalopathy.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> The rate of respiratory depression at birth with delay in respiration was 5.2\/1000, with Apgar \u2264 3 1.0\/1000 live births, and with neonatal seizures 0.7\/1000. A composite of any of the three respiratory depressions at birth criteria showed comparable low rates with spontaneous delivery (4.4\/1000) and elective caesarean (4.8\/1000). Compared with elective caesarean delivery, vacuum (13.2\/1000, relative risk [RR] 3.97, <jats:italic>P<\/jats:italic> &lt; 0.001), forceps (8.8\/1000, RR 1.84, <jats:italic>P<\/jats:italic>= 0.003), failed vacuum (13.3\/1000, RR 2.76, <jats:italic>P<\/jats:italic>= 0.005), failed forceps (33.3\/1000, RR 6.93, <jats:italic>P<\/jats:italic> &lt; 0.001), and caesarean in labour (17.0\/1000, RR 3.54, <jats:italic>P<\/jats:italic> &lt; 0.001) had significantly higher rates of the composite outcome.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> Overall, the rate of respiratory depression at birth in the term infant was low and the serious manifestation of seizures was less than 1 in 1000. There was a significant relationship between operative delivery in labour and respiratory depression at birth.<\/jats:p>","DOI":"10.1111\/j.1471-0528.2006.00987.x","type":"journal-article","created":{"date-parts":[[2006,6,22]],"date-time":"2006-06-22T16:58:29Z","timestamp":1150995509000},"page":"769-774","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Predictors of respiratory depression at birth in the term infant"],"prefix":"10.1111","volume":"113","author":[{"given":"TF","family":"Baskett","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"VM","family":"Allen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CM","family":"O\u2018Connell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"AC","family":"Allen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,6,22]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.20.2677"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12658-X"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0412.2002.811003.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.05.013"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7211259"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2004.03.008"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2004.04.011"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2003.048785"},{"key":"e_1_2_6_10_2","first-page":"463","article-title":"MR imaging quantification of cerebellar growth following hypoxic\u2010ischemic injury to the neonatal brain","volume":"25","author":"Le Strange E","year":"2004","journal-title":"Am J Neuroradiol"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2002.tb02919.x"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.317.7172.1549"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.317.7172.1554"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2003.09.015"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)81615-4"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(97)70072-6"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7211023"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1754.2000.00518.x"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2000.tb18426.x"},{"key":"e_1_2_6_20_2","first-page":"F257","volume":"90","author":"Marlow N","year":"2005","journal-title":"Prevalence, causes, and outcome at 2 years of age of newborn encephalopathy"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000127035.64602.97"},{"key":"e_1_2_6_22_2","unstructured":"Statistics Canada.Census Nation Tables.2001[www40.statcan.ca\/101\/cst01\/demo.htm]. 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