{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T11:25:11Z","timestamp":1791890711976,"version":"4.3.4"},"reference-count":37,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2006,7,7]],"date-time":"2006-07-07T00:00:00Z","timestamp":1152230400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:p><jats:bold>Objective\u2002<\/jats:bold> To evaluate the prognostic impact of elevated total vascular resistance (TVR) on the outcome of pregnancy in early mild gestational hypertension (EMGH).<\/jats:p><jats:p><jats:bold>Design\u2002<\/jats:bold> Prospective observational study.<\/jats:p><jats:p><jats:bold>Setting\u2002<\/jats:bold> Data collected from women with EMGH referred to the obstetrics outpatient clinic of Tor Vergata University from June 2003 to June 2005.<\/jats:p><jats:p><jats:bold>Population\u2002<\/jats:bold> A total of 268 women with EMGH (systolic and diastolic blood pressure [BP] 140\u2013150 mmHg and 90\u201399 mmHg, respectively, without significant proteinuria).<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Women had a maternal echocardiographic examination and BP examination within 24 hours of diagnosis. From this, the TVR was calculated and the geometric pattern of the left ventricle assessed.<\/jats:p><jats:p><jats:bold>Main outcome measures\u2002<\/jats:bold> Fetal\/maternal adverse outcomes (pre\u2010eclampsia, preterm delivery, placental abruption, other maternal medical problems, fetal distress, neonatal low birthweight, admittance to neonatal intensive care unit and perinatal death).<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Ninety\u2010two out of the 268 pregnancies showed adverse outcomes (34.3%). The best independent predictor for the composite of maternal and fetal complications was TVR (OR 64.4, 95% CI 25.9\u2013160.1). The cutoff value was 1340 dyn seconds\/cm<jats:sup>5<\/jats:sup> with a sensitivity and a specificity of 90 and 91%, respectively. Concentric geometry of the left ventricle was also an independent predictor (OR 4.72, 95% CI 1.85\u201312.04).<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Echocardiography could help in identifying women with EMGH who subsequently develop maternal and fetal complications, allowing a classification in high\u2010risk (TVR &gt; 1340 dyn seconds\/cm<jats:sup>5<\/jats:sup>, concentric geometry of the left ventricle) and low\u2010risk women (TVR &lt; 1340 dyn seconds\/cm<jats:sup>5<\/jats:sup>, nonconcentric geometry of the left ventricle) for adverse outcomes of pregnancy.<\/jats:p>","DOI":"10.1111\/j.1471-0528.2006.01013.x","type":"journal-article","created":{"date-parts":[[2006,7,7]],"date-time":"2006-07-07T23:19:52Z","timestamp":1152314392000},"page":"1044-1052","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Maternal total vascular resistance and concentric geometry: a key to identify uncomplicated gestational hypertension"],"prefix":"10.1111","volume":"113","author":[{"given":"H","family":"Valensise","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Vasapollo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GP","family":"Novelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Pasqualetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Galante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Arduini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,7]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2001.112905"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(88)90090-7"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2002.00847.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.1095"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0028-2243(93)90265-E"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1997.09020094.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1996.07030182.x"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2001.00382.x"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(84)90357-0"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.17.6.1072"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.37.5.1209"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-7061(00)01264-4"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-7061(00)01250-4"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00966.2001"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000058001.67791.0A"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016345909157991"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016346209158082"},{"key":"e_1_2_6_19_2","first-page":"163","article-title":"Maternal hemodynamics and impaired fetal growth in pregnancy\u2010induced hypertension","volume":"71","author":"Nisell H","year":"1988","journal-title":"Obstet Gynecol"},{"key":"e_1_2_6_20_2","first-page":"265","article-title":"Maternal left ventricular dimension in pregnancies complicated by fetal growth retardation","volume":"78","author":"Veille JC","year":"1991","journal-title":"Obstet Gynecol"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016349509021176"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0029-7844(94)00417-C"},{"key":"e_1_2_6_23_2","first-page":"907","article-title":"Report of the Canadian Hypertension Society Consensus Conference: 2. 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