{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T06:05:52Z","timestamp":1787983552716,"version":"build-2784847793"},"reference-count":38,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2006,9,13]],"date-time":"2006-09-13T00:00:00Z","timestamp":1158105600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:p><jats:bold>Objective\u2002<\/jats:bold> To determine the risk of metabolic syndrome (MS) and polycystic ovary syndrome (PCOS) in a cohort of indigenous South Asian women with a recent history of gestational diabetes mellitus (GDM).<\/jats:p><jats:p><jats:bold>Design\u2002<\/jats:bold> Case\u2013control study.<\/jats:p><jats:p><jats:bold>Setting\u2002<\/jats:bold> Department of Obstetrics &amp; Gynaecology, University of Colombo, Sri Lanka.<\/jats:p><jats:p><jats:bold>Sample\u2002<\/jats:bold> Two hundred and seventy\u2010four indigenous Sri Lankan women with previous GDM and 168 ethnically matched controls. Of these, 147 with previous GDM and 67 controls not taking hormonal contraception participated in an in\u2010depth endocrine study.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Assessing the prevalence of MS and PCOS based on clinical features, biochemistry and ovarian ultrasound examination at 3 years postpartum.<\/jats:p><jats:p><jats:bold>Main outcome measures\u2002<\/jats:bold> Prevalence of MS and PCOS.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Women with previous GDM and controls were studied at a mean (range) of 34.6 (13.4\u201384.1) and 46.5 (17.5\u201378) months postpartum, respectively. Those with previous GDM had a larger mean \u00b1 95% confidence interval waist circumference (90.9 \u00b1 1.3 versus 81.2 \u00b1 2.8 cm, <jats:italic>P<\/jats:italic>= 0.0004) and were more likely to have hypertension (17.6 versus 7.4%, <jats:italic>P<\/jats:italic>= 0.001), glucose intolerance (51.7 versus 10.4%, <jats:italic>P<\/jats:italic>= 0.00001), hypertriglyceridaemia (16.3 versus 5.9%, <jats:italic>P<\/jats:italic>= 0.02) and a lower level of high\u2010density lipoprotein (70 versus 56.7%, <jats:italic>P<\/jats:italic>= 0.04) than the controls. Of the women who had GDM, 72 (49%) had MS, 86 (58.5%) had polycystic ovaries and 59 (40%) had PCOS, significantly more than the control women\u20144 (6%), 9 (13%) and 2 (3%), respectively (<jats:italic>P<\/jats:italic>= 0.00001).<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> The prevalence of MS and PCOS in indigenous Sri Lankan women 3 years postpartum is significantly higher in those with previous GDM compared with ethnically matched controls. This confirms an association between GDM and subsequent PCOS and MS.<\/jats:p>","DOI":"10.1111\/j.1471-0528.2006.01046.x","type":"journal-article","created":{"date-parts":[[2006,9,13]],"date-time":"2006-09-13T15:00:05Z","timestamp":1158159605000},"page":"1182-1187","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Metabolic and polycystic ovary syndromes in indigenous South Asian women with previous gestational diabetes mellitus"],"prefix":"10.1111","volume":"113","author":[{"given":"CN","family":"Wijeyaratne","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Waduge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Arandara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Arasalingam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Sivasuriam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SH","family":"Dodampahala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AH","family":"Balen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,9,13]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.559633"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.56.082103.104751"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03345554"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200524531"},{"key":"e_1_2_8_6_2","first-page":"495","article-title":"Gestational diabetes mellitus and subsequent development of overt diabetes mellitus","volume":"45","author":"Damm P","year":"1998","journal-title":"Dan Med Bull"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.20.11.1717"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.21.9.1414"},{"key":"e_1_2_8_9_2","first-page":"33","article-title":"Type 2 diabetes: the epidemic of the new millennium","volume":"29","author":"Jovanovic L","year":"1999","journal-title":"Ann Clin Lab Sci"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-004-1387-6"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.25.1.72"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1262-3636(07)70205-7"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.1993.tb02371.x"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.2337\/diab.40.2.S35"},{"key":"e_1_2_8_15_2","first-page":"213","article-title":"Risk factors for coronary heart disease among immigrant women from Iran and Turkey compared to women of Swedish ethnicity","volume":"15","author":"Daryani A","year":"2005","journal-title":"Ethn Dis"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.72.5.413"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9136(199602)13:2<189::AID-DIA32>3.0.CO;2-4"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8227(03)00085-8"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.4038\/cmj.v50i2.1571"},{"key":"e_1_2_8_20_2","unstructured":"World Health Organization.Definition diagnosis and classification of diabetes mellitus. 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