{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T02:55:27Z","timestamp":1722394527539},"reference-count":19,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2006,9,27]],"date-time":"2006-09-27T00:00:00Z","timestamp":1159315200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:p><jats:bold>Objectives\u2002<\/jats:bold> To assess whether lactate determination in vaginal fluid is associated with, and can predict, onset of labour for women with suspected prelabour rupture of the membranes (PROM).<\/jats:p><jats:p><jats:bold>Design\u2002<\/jats:bold> Prospective observational study.<\/jats:p><jats:p><jats:bold>Setting\u2002<\/jats:bold> Labour ward at Soder Hospital, Stockholm, Sweden.<\/jats:p><jats:p><jats:bold>Population\u2002<\/jats:bold> Women with suspected PROM after 34 weeks of gestation, who later had spontaneous onset of labour (<jats:italic>n<\/jats:italic>= 179).<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> All women underwent a speculum examination and a test for determining lactate concentration in vaginal fluid. We used logistic regression to estimate the association between lactate concentration in vaginal fluid and time to onset of labour.<\/jats:p><jats:p><jats:bold>Main outcome measures\u2002<\/jats:bold> Time from examination to onset of labour (cervix \u22654 cm), within 24 hours and 48 hours.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> The median time interval between examination and spontaneous onset of labour was 8.4 hours for women with \u2018high\u2019 lactate (\u22654.5 mmol\/l) and 54 hours for those with \u2018low\u2019 lactate concentrations (&lt;4.5 mmol\/l). Among 86 women with high lactate concentrations, 76 (88%) had started labour within 24 hours compared with 20 of 93 (22%) women with low lactate concentrations (OR 27.7, 95% CI 12.2\u201363.3). After checking for the effect of visible amniotic fluid, the corresponding odds were still substantially increased (OR 13.5, 95% CI 5.3\u201334.3).<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> High lactate concentration (\u22654.5 mmol\/l) in vaginal fluid can be used to predict whether a woman with suspected PROM will commence spontaneous onset of labour within 24 or 48 hours.<\/jats:p>","DOI":"10.1111\/j.1471-0528.2006.01088.x","type":"journal-article","created":{"date-parts":[[2006,9,27]],"date-time":"2006-09-27T09:44:06Z","timestamp":1159350246000},"page":"1426-1430","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Association between lactate in vaginal fluid and time to spontaneous onset of labour for women with suspected prelabour rupture of the membranes"],"prefix":"10.1111","volume":"113","author":[{"given":"E","family":"Wiberg\u2010Itzel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Pettersson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Cnattingius","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Nordstrom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,11,10]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1996.tb09869.x"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-200010000-00010"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199604183341601"},{"key":"e_1_2_6_5_2","unstructured":"LadforsL.Prelabour rupture of the membranes at or near term: clinical and epidemiological studies. 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