{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:45:31Z","timestamp":1791398731150,"version":"4.3.3"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,12,4]],"date-time":"2006-12-04T00:00:00Z","timestamp":1165190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2007,3]]},"abstract":"<jats:p><jats:bold>Objective\u2002<\/jats:bold> To evaluate whether magnesium sulphate (MgSO<jats:sub>4<\/jats:sub>) given to women at risk of very\u2010preterm birth would be neuroprotective in preterm newborns and would prevent neonatal mortality and severe white\u2010matter injury (WMI).<\/jats:p><jats:p><jats:bold>Design\u2002<\/jats:bold> A randomised study.<\/jats:p><jats:p><jats:bold>Setting\u2002<\/jats:bold> Eighteen French tertiary hospitals.<\/jats:p><jats:p><jats:bold>Population\u2002<\/jats:bold> Women with fetuses of gestational age &lt; 33 weeks whose birth was planned or expected within 24 hours were enrolled from July 1997 to July 2003 with follow up of infants until hospital discharge.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Five hundred and seventy\u2010three mothers were randomly assigned to receive a single 40\u2010ml infusion of 0.1 g\/ml of MgSO<jats:sub>4<\/jats:sub> (4 g) solution or isotonic 0.9% saline (placebo) over 30 minutes. This study is registered as an International Standard Randomised Controlled Trial, number 00120588.<\/jats:p><jats:p><jats:bold>Main outcome measures\u2002<\/jats:bold> The primary endpoints were rates of severe WMI or total mortality before hospital discharge, and their combined outcome. Analyses were based on intention to treat.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> After 6 years of enrolment, the trial was stopped. Data from 688 infants were analysed. Comparing infants who received MgSO<jats:sub>4<\/jats:sub> or placebo, respectively, total mortality (9.4 versus 10.4%; OR: 0.79, 95% CI 0.44\u20131.44), severe WMI (10.0 versus 11.7%; OR: 0.78, 95% CI 0.47\u20131.31) and their combined outcomes (16.5 versus 17.9%; OR: 0.86, 95% CI 0.55\u20131.34) were less frequent for the former, but these differences were not statistically significant. No major maternal adverse effects were observed in the MgSO<jats:sub>4<\/jats:sub> group.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> Although our results are inconclusive, improvements of neonatal outcome obtained with MgSO<jats:sub>4<\/jats:sub> are of potential clinical significance. More research is needed to assess the protective effect of MgSO<jats:sub>4<\/jats:sub> alone or in combination with other neuroprotective molecules.<\/jats:p>","DOI":"10.1111\/j.1471-0528.2006.01162.x","type":"journal-article","created":{"date-parts":[[2006,12,5]],"date-time":"2006-12-05T11:04:39Z","timestamp":1165316679000},"page":"310-318","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":237,"title":["Magnesium sulphate given before very\u2010preterm birth to protect infant brain: the randomised controlled PREMAG trial*"],"prefix":"10.1111","volume":"114","author":[{"given":"S","family":"Marret","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Marpeau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Zupan\u2010Simunek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Eurin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"L\u00e9v\u00eaque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u2010F","family":"Hellot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"B\u00e9nichou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"PREMAG trial group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,12,4]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2002.019752"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000161375.55172.3f"},{"key":"e_1_2_7_4_2","first-page":"373","article-title":"Grand prematurity, risk of neuropsychic handicaps and neuroprotection","volume":"29","author":"Marret S","year":"2000","journal-title":"J Gynecol Obstet Biol Reprod (Paris)"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/088307380101600603"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1067\/S0022-3476(03)00417-7"},{"key":"e_1_2_7_7_2","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1542\/peds.95.2.263","article-title":"Can magnesium sulphate reduce the risk of cerebral palsy in very low birth weight infants?","volume":"95","author":"Nelson KB","year":"1995","journal-title":"Pediatrics"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(95)91270-3"},{"key":"e_1_2_7_9_2","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1001\/jama.1996.03540220029026","article-title":"Prenatal magnesium sulphate exposure and the risk of cerebral palsy or mental retardation among very\u2010low\u2010birth\u2010weight children aged 3 to 5 years","volume":"276","author":"Schendel DE","year":"1996","journal-title":"JAMA"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-994149"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1053\/ob.1996.v175.a73596"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(98)00455-4"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a009458"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.20.2669"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1996.tb15068.x"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)92471-X"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.11.057"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/fn.84.2.F92"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.104.2.243"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/0471722146"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(98)00163-X"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa012750"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1067\/S0022-3476(03)00357-3"},{"key":"e_1_2_7_24_2","first-page":"28","article-title":"Role of magnesium and other divalent cations in ATP\u2010utilizing enzymes","volume":"6","author":"Mildvan A","year":"1987","journal-title":"Magnesium"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(89)91188-8"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(90)90569-U"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199307000-00006"},{"key":"e_1_2_7_28_2","first-page":"473","article-title":"Prevention by magnesium of excitotoxic neuronal death in the developing brain: an animal model for clinical intervention studies","volume":"37","author":"Marret S","year":"1995","journal-title":"Dev Med Child Neurol"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.284.11.1417"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(95)91357-2"},{"key":"e_1_2_7_31_2","first-page":"111","article-title":"Enhanced release of IL\u20101beta and TNF\u2010alpha following endotoxin challenge from rat alveolar macrophages cultured in low\u2010Mg(2+) medium","volume":"16","author":"Shogi T","year":"2003","journal-title":"Magnes Res"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2004.02.004"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)78242-8"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)78241-6"},{"key":"e_1_2_7_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)78240-4"},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)78239-8"}],"container-title":["BJOG: An International Journal of Obstetrics &amp; Gynaecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1471-0528.2006.01162.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1471-0528.2006.01162.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T09:34:56Z","timestamp":1697016896000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/j.1471-0528.2006.01162.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,12,4]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2007,3]]}},"alternative-id":["10.1111\/j.1471-0528.2006.01162.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1471-0528.2006.01162.x","archive":["Portico"],"relation":{},"ISSN":["1470-0328","1471-0528"],"issn-type":[{"value":"1470-0328","type":"print"},{"value":"1471-0528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,12,4]]},"assertion":[{"value":"2006-12-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}