{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T05:57:00Z","timestamp":1767851820300,"version":"3.49.0"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,1,9]],"date-time":"2007-01-09T00:00:00Z","timestamp":1168300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:p><jats:bold>Objective\u2002<\/jats:bold> To investigate the role of pentraxin 3 (PTX3), an acute\u2010phase protein produced by cells of innate immunity in response to inflammatory signals, in spontaneous preterm delivery (PTD).<\/jats:p><jats:p><jats:bold>Design\u2002<\/jats:bold> Cohort study.<\/jats:p><jats:p><jats:bold>Setting\u2002<\/jats:bold> Department of Obstetrics and Gynecology of the University of Milano\u2010Bicocca.<\/jats:p><jats:p><jats:bold>Population\u2002<\/jats:bold> Forty\u2010six pregnant women with preterm rupture of membranes (<jats:italic>n<\/jats:italic>= 33) or preterm labour with intact membranes (<jats:italic>n<\/jats:italic>= 13) delivering at &lt;34 weeks of gestation and 34 women with uncomplicated pregnancies (control group).<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> We compared plasma and vaginal PTX3 levels between study group and controls, and in women with versus women without clinical or histologic evidence of intrauterine infection using statistical analysis.<\/jats:p><jats:p><jats:bold>Main outcome measures\u2002<\/jats:bold> Peak PTX3 concentration.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Peak PTX3 concentration in plasma samples of study group was significantly higher than that in controls (1175, 0\u20139630 versus 650, 0\u20131450 pg\/ml; <jats:italic>P<\/jats:italic>= 0.0003) but not in vaginal swabs (1660, 0\u20136604 versus 457, 0\u20134649 pg\/ml; <jats:italic>P<\/jats:italic>= 0.386). PTX3 levels in plasma were significantly higher in women with placenta vasculopathy compared with that in women with no placental lesions (2910, 0\u20139630 versus 636, 0\u20135692 pg\/ml; <jats:italic>P<\/jats:italic>= 0.04). Peak plasma and vaginal PTX3 concentrations were not significantly different in women with versus women without intrauterine infection (1168, 0\u20137110 versus 845, 0\u20139630 pg\/ml, <jats:italic>P<\/jats:italic>= 0.34 and 1975, 471\u20136604 versus 1919, 0\u20134150 pg\/ml, <jats:italic>P<\/jats:italic>= 0.38, respectively).<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Spontaneous PTD is associated with a significant increase of maternal plasma concentrations of PTX3. PTX3 seems to be a marker of placenta vasculopathy rather than intrauterine infection.<\/jats:p>","DOI":"10.1111\/j.1471-0528.2006.01225.x","type":"journal-article","created":{"date-parts":[[2007,1,9]],"date-time":"2007-01-09T23:25:24Z","timestamp":1168385124000},"page":"143-147","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Pentraxin 3 in plasma and vaginal fluid in women with preterm delivery*"],"prefix":"10.1111","volume":"114","author":[{"given":"F","family":"Assi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Fruscio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Bonardi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Ghidini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Allavena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Mantovani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Locatelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,1,9]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0412.2003.00218.x"},{"issue":"20","key":"e_1_2_6_3_2","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1046\/j.1471-0528.2003.00025.x","article-title":"The role of infection in preterm labour","volume":"110","author":"Friese K","year":"2003","journal-title":"BJOG"},{"issue":"20","key":"e_1_2_6_4_2","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1046\/j.1471-0528.2003.00062.x","article-title":"Role of cytokines and other inflammatory mediators","volume":"110","author":"Winkler M","year":"2003","journal-title":"BJOG"},{"key":"e_1_2_6_5_2","doi-asserted-by":"crossref","first-page":"22190","DOI":"10.1016\/S0021-9258(18)41653-5","article-title":"Interleukin\u20101 inducible genes in endothelial cells. Cloning of a new gene related to C\u2010reactive protein and serum amyloid P component","volume":"267","author":"Breviario F","year":"1992","journal-title":"J Biol Chem"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.23.021704.115756"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2776(08)60379-X"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.26.14584"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V84.10.3483.3483"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature01195"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200107000-00017"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.6.636"},{"key":"e_1_2_6_13_2","first-page":"647","article-title":"College of American Pathologists Conference XIX on the examination of the placenta: report of the working group on the definition of structural changes associated with abnormal functions in the maternal\u2010fetal\u2010placental unit in the second and third trimesters","volume":"115","author":"Lowell DM","year":"1991","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0412.2003.00156.x"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2005.11.018"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000224607.46622.bc"}],"container-title":["BJOG: An International Journal of Obstetrics &amp; Gynaecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1471-0528.2006.01225.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1471-0528.2006.01225.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T13:52:47Z","timestamp":1697032367000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/j.1471-0528.2006.01225.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1,9]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,2]]}},"alternative-id":["10.1111\/j.1471-0528.2006.01225.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1471-0528.2006.01225.x","archive":["Portico"],"relation":{},"ISSN":["1470-0328","1471-0528"],"issn-type":[{"value":"1470-0328","type":"print"},{"value":"1471-0528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,1,9]]},"assertion":[{"value":"2007-01-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}