{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T03:10:32Z","timestamp":1793070632808,"version":"4.5.0"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,1,25]],"date-time":"2007-01-25T00:00:00Z","timestamp":1169683200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2007,3]]},"abstract":"<jats:p><jats:bold>Objective\u2002<\/jats:bold> The aim of the study was to elucidate the reason for the high rate of caesarean section in obese women. We examined the following hypotheses: (1) obese women have a high incidence of complications related to poor uterine contractility\u2014caesarean section for dysfunctional labour and postpartum haemorrhage. 2) The myometrium from obese women has less ability to contract <jats:italic>in vitro<\/jats:italic>.<\/jats:p><jats:p><jats:bold>Design\u2002<\/jats:bold> First, a clinical retrospective analysis of data from 3913 completed singleton pregnancies was performed. Secondly, in a prospective study the force, frequency and intracellular [Ca<jats:sup>2+<\/jats:sup>] flux of spontaneously contracting myometrium were related to the maternal body mass index.<\/jats:p><jats:p><jats:bold>Setting\u2002<\/jats:bold> Liverpool Women\u2019s Hospital and University of Liverpool.<\/jats:p><jats:p><jats:bold>Population\u2002<\/jats:bold> The clinical study involved all women who delivered in one hospital in 2002. The <jats:italic>in vitro<\/jats:italic> study myometrial biopsies were obtained from 73 women who had elective caesarean section at term.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Maternal obesity carried significant risk of caesarean section in labour that was highest for delay in the first stage of labour (OR 3.54). The increased risk of caesarean section in obese women largely occurred in women with normal\u2010 and not with high\u2010birthweight infants. Obese women delivering vaginally had increased risk of prolonged first stage of labour and excessive blood loss. Myometrium from obese women contracted with less force and frequency and had less [Ca<jats:sup>2+<\/jats:sup>] flux than that from normal\u2010weight women.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> We suggest that these findings indicate that obesity may impair the ability of the uterus to contract in labour.<\/jats:p>","DOI":"10.1111\/j.1471-0528.2006.01233.x","type":"journal-article","created":{"date-parts":[[2007,1,25]],"date-time":"2007-01-25T13:48:39Z","timestamp":1169732919000},"page":"343-348","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":290,"title":["Poor uterine contractility in obese women"],"prefix":"10.1111","volume":"114","author":[{"given":"J","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Bricker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Wray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Quenby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,1,25]]},"reference":[{"key":"e_1_2_7_2_2","unstructured":"The World Health Organization.Obesity: Preventing and Managing the Global Epidemic. Geneva:WHO 1998."},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(96)00449-8"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1515\/JPM.2001.046"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2003.09.058"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000107291.46159.00"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2002.126200"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0802714"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00232-004-0663-1"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000023438.32585.A1"},{"key":"e_1_2_7_11_2","article-title":"Increased cholesterol decreases uterine activity: functional effects of cholesterol in pregnant rat myometrium","author":"Smith RD","year":"2004","journal-title":"Am J Physiol"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/35036052"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.32.3.459"},{"key":"e_1_2_7_14_2","first-page":"307","article-title":"Interactive role of tyrosine kinase, protein kinase C, and Rho\/Rho kinase systems in the mechanotransduction of vascular smooth muscles","volume":"40","author":"Nakayama K","year":"2003","journal-title":"Biorheology"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1327.2000.01280.x"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1095-6433(98)10118-6"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-020311"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1159\/000010038"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(16)35734-9"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(76)90517-2"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000142713.53197.91"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0028-2243(92)90190-A"},{"key":"e_1_2_7_23_2","first-page":"22","article-title":"Characteristics of lipid composition of the blood serum in obese pregnant women","author":"Pobedinskii NM","year":"1987","journal-title":"Akush Ginekol (Mosk)"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1071-5576(03)00089-3"},{"key":"e_1_2_7_25_2","first-page":"187","article-title":"Ion channels, membrane lipids and cholesterol: a role for membrane lipid domains in arterial function","volume":"334","author":"Tulenko TN","year":"1990","journal-title":"Prog Clin Biol Res"}],"container-title":["BJOG: An International Journal of Obstetrics &amp; Gynaecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1471-0528.2006.01233.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1471-0528.2006.01233.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T13:35:28Z","timestamp":1697031328000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/j.1471-0528.2006.01233.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1,25]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2007,3]]}},"alternative-id":["10.1111\/j.1471-0528.2006.01233.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1471-0528.2006.01233.x","archive":["Portico"],"relation":{},"ISSN":["1470-0328","1471-0528"],"issn-type":[{"value":"1470-0328","type":"print"},{"value":"1471-0528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,1,25]]},"assertion":[{"value":"2007-01-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}