{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T05:42:40Z","timestamp":1790228560996,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,3,9]],"date-time":"2007-03-09T00:00:00Z","timestamp":1173398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2007,4]]},"abstract":"<jats:p>\n                    <jats:bold>Background\u2002<\/jats:bold>\n                    Amnioinfusion (AI) is thought to dilute meconium when present in the amniotic fluid and so reduces the risk of meconium aspiration.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Objectives\u2002<\/jats:bold>\n                    To evaluate if AI reduces meconium aspiration syndrome (MAS) and other indicators of morbidity in babies born to women with meconium\u2010stained amniotic fluid (MSAF).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Search strategy\u2002<\/jats:bold>\n                    PubMed, Medline, EMBASE, and the Cochrane Controlled Trials Register from January 1980 to May 30, 2005, using the keywords \u2018amnioinfusion\u2019 and \u2018meconium\u2019.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Selection criteria\u2002<\/jats:bold>\n                    Randomised trials comparing AI with no AI for women in labour with MSAF. Trial quality was evaluated using pre\u2010established criteria.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Data collection and analysis\u2002<\/jats:bold>\n                    The following morbidity indicators were assessed: MAS, 5\u2010minute Apgar score &lt; 7, arterial cord pH &lt; 7.2, and caesarean section. Studies were stratified according to the level of peripartum surveillance (standard versus limited). Typical relative risks (RRs) with their 95% confidence intervals were calculated for each outcome using a random effects model.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Main results\u2002<\/jats:bold>\n                    In clinical settings with standard peripartum surveillance, we found no evidence that AI reduced the risk of MAS (RR 0.59, 95% CI 0.28\u20131.25), 5\u2010minute Apgar score &lt; 7 (RR 0.90, 95% CI 0.58\u20131.41), or caesarean delivery (RR 0.89, 95% CI 0.73\u20131.10). In clinical settings with limited peripartum surveillance, AI appeared to reduce the risk of MAS (RR 0.25, 95% CI 0.13\u20130.47).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion\u2002<\/jats:bold>\n                    In clinical settings with standard peripartum surveillance, the evidence does not support the use of AI for MSAF. In settings with limited peripartum surveillance, where complications of MSAF are common, AI appears to reduce the risk of MAS. However, this finding requires confirmation by further studies.\n                  <\/jats:p>","DOI":"10.1111\/j.1471-0528.2007.01262.x","type":"journal-article","created":{"date-parts":[[2007,3,9]],"date-time":"2007-03-09T11:46:30Z","timestamp":1173440790000},"page":"383-390","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Intrapartum amnioinfusion for meconium\u2010stained amniotic fluid: a systematic review of randomised controlled trials"],"prefix":"10.1111","volume":"114","author":[{"given":"H","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Hofmeyr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Roy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"WD","family":"Fraser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,3,9]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1542\/peds.85.5.715","article-title":"Meconium aspiration syndrome: have we made a difference?","volume":"85","author":"Wiswell TE","year":"1990","journal-title":"Pediatrics"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(75)90973-4"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(88)90134-2"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016348209156571"},{"key":"e_1_2_5_6_2","first-page":"296","article-title":"Perinatal characteristics of uncomplicated postdate pregnancies","volume":"69","author":"Eden RD","year":"1987","journal-title":"Obstet Gynecol"},{"key":"e_1_2_5_7_2","first-page":"715","article-title":"Interrelationships among abnormal cardiotocograms in labor, meconium staining of the amniotic fluid, arterial cord blood pH and Apgar scores","volume":"74","author":"Steer PJ","year":"1989","journal-title":"Obstet Gynecol"},{"key":"e_1_2_5_8_2","first-page":"26","article-title":"Intrauterine meconium aspiration","volume":"57","author":"Brown BL","year":"1981","journal-title":"Obstet Gynecol"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(85)90506-X"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.1996.tb02180.x"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(93)90132-3"},{"key":"e_1_2_5_12_2","first-page":"349","article-title":"Failure to prevent meconium aspiration syndrome","volume":"71","author":"Falciglia HS","year":"1988","journal-title":"Obstet Gynecol"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1989.tb02414.x"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD000014"},{"key":"e_1_2_5_15_2","first-page":"322","article-title":"Effect of amnioinfusion for meconium stained amniotic fluid on perinatal outcome","volume":"54","author":"Ashfaq F","year":"2004","journal-title":"J Pak Med Assoc"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02730651"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050223"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(01)00354-2"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2002.01140.x"},{"key":"e_1_2_5_20_2","first-page":"677","article-title":"Prophylactic amnioinfusion in pregnancies complicated by oligohydramnios: a prospective study","volume":"77","author":"Nageotte MP","year":"1991","journal-title":"Obstet Gynecol"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.1993.tb02053.x"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.1997.tb02412.x"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7210732"},{"key":"e_1_2_5_24_2","article-title":"Prophylactic transabdominal amnioinfusion during labor with thick meconium: does it work?","volume":"86","author":"Lembet A","year":"1999","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-0997(1999)7:3<153::AID-IDOG7>3.0.CO;2-2"},{"key":"e_1_2_5_26_2","first-page":"365","article-title":"Transcervical amnioinfusion in deliveries with meconium\u2010stained amniotic fluid","volume":"42","author":"Alvarez M","year":"1999","journal-title":"Progresos de Obstetricia y Ginecologia"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(95)00134-4"},{"key":"e_1_2_5_28_2","unstructured":"AdamK CanoL MoiseKJ.The effect of intrapartum amnioinfusion on the outcome of the fetus with heavy meconium stained amniotic fluid. 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