{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T08:24:46Z","timestamp":1769761486724,"version":"3.49.0"},"reference-count":12,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2007,6,18]],"date-time":"2007-06-18T00:00:00Z","timestamp":1182124800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2007,8]]},"abstract":"<jats:p> <jats:bold>Objective\u2002<\/jats:bold>To determine the effects of magnesium supplementation in pregnancy on the incidence of hypoxic\u2010ischaemic encephalopathy (HIE).<\/jats:p><jats:p> <jats:bold>Design\u2002<\/jats:bold>A randomised double\u2010blind placebo\u2010controlled study.<\/jats:p><jats:p> <jats:bold>Setting\u2002<\/jats:bold>A Midwife Obstetric Unit and its two referral hospitals in Cape Town, South Africa.<\/jats:p><jats:p> <jats:bold>Population\u2002<\/jats:bold>A group of 4494 black pregnant women of low socio\u2010economic status.<\/jats:p><jats:p> <jats:bold>Method\u2002<\/jats:bold>Mothers, from the time of booking until delivery, were randomised to receive two identical tablets daily, containing either 128 mg slow\u2010release magnesium stearate or lactose sugar.<\/jats:p><jats:p> <jats:bold>Main outcome measures\u2002<\/jats:bold>Primary: The incidence of HIE. Secondary: The incidence of fetal heart rate decelerations, term Stillbirths, Low Apgar Scores, Meconium Aspiration Pneumonia.<\/jats:p><jats:p> <jats:bold>Results\u2002<\/jats:bold>The incidence of HIE (0.9%) was considerably less than anticipated (2%). There were 22 infants in the placebo group and 15 infants in the supplemented group (<jats:italic>P<\/jats:italic>= 0.279). The difference was not significant.<\/jats:p><jats:p>Secondary outcomes such as late fetal heart rate decelerations (<jats:italic>P<\/jats:italic>= 0.002) and term stillbirths (<jats:italic>P<\/jats:italic>= 0.016) were reduced significantly in the supplemented group, but this finding needs further substantiation.<\/jats:p><jats:p> <jats:bold>Conclusions\u2002<\/jats:bold>Magnesium supplementation did not reduce the incidence of HIE significantly, probably because the study was underpowered and compliance was relatively poor.<\/jats:p>","DOI":"10.1111\/j.1471-0528.2007.01409.x","type":"journal-article","created":{"date-parts":[[2007,6,18]],"date-time":"2007-06-18T12:03:45Z","timestamp":1182168225000},"page":"994-1002","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Magnesium supplementation and perinatal hypoxia: outcome of a parallel group randomised trial in pregnancy"],"prefix":"10.1111","volume":"114","author":[{"given":"V","family":"Harrison","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Fawcus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Jordaan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,6,18]]},"reference":[{"key":"e_1_2_8_2_2","volume-title":"Proceedings of the 23rd Conference in Perinatal Care in Southern Africa","author":"Linley L","year":"2004"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-3782(96)01787-2"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(79)80734-9"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1997.tb08581.x"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1983.04050050029002"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(79)90114-5"},{"key":"e_1_2_8_8_2","volume-title":"The Cochrane Library","author":"Makrides M","year":"2005"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1991.tb13515.x"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.22.4.417"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1080\/02724936.1991.11747524"},{"key":"e_1_2_8_12_2","volume-title":"Guidelines for Perinatal Care","author":"Hauth JC","year":"1997"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68586-3"}],"container-title":["BJOG: An International Journal of Obstetrics &amp; Gynaecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1471-0528.2007.01409.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1471-0528.2007.01409.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T12:25:49Z","timestamp":1697027149000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/j.1471-0528.2007.01409.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,6,18]]},"references-count":12,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2007,8]]}},"alternative-id":["10.1111\/j.1471-0528.2007.01409.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1471-0528.2007.01409.x","archive":["Portico"],"relation":{},"ISSN":["1470-0328","1471-0528"],"issn-type":[{"value":"1470-0328","type":"print"},{"value":"1471-0528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,6,18]]},"assertion":[{"value":"2007-06-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}