{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T07:08:22Z","timestamp":1790752102315,"version":"4.1.0"},"reference-count":122,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2008,1,8]],"date-time":"2008-01-08T00:00:00Z","timestamp":1199750400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2008,2]]},"abstract":"<jats:p>Anorexia nervosa (AN) initiates an adaptive response at the level of the hypothalamus, which results in a complex interplay involving most elements of the neuroendocrine axis. Consequences of onset of disease in adolescence include amenorrhoea, pubertal arrest with potential loss of target height, and osteoporosis with reduced capacity for future attainment of peak bone mass. With recovery, delay in restoration of menses is common. Hormonal therapies for restoration of bone mineral density (BMD) in adolescents have shown limited efficacy. This review will discuss the reproductive endocrine effects of AN in adolescence, and discuss new investigative tools for monitoring restoration of reproductive function and BMD in this population.<\/jats:p>","DOI":"10.1111\/j.1471-0528.2007.01601.x","type":"journal-article","created":{"date-parts":[[2008,1,8]],"date-time":"2008-01-08T15:27:10Z","timestamp":1199806030000},"page":"304-315","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Current concepts in bone and reproductive health in adolescents with anorexia nervosa"],"prefix":"10.1111","volume":"115","author":[{"given":"Y","family":"Jayasinghe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SR","family":"Grover","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Zacharin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,1,8]]},"reference":[{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1053\/ybeog.2003.0344"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa040388"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/372425a0"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)66830-4"},{"key":"e_1_2_10_6_2","volume-title":"Diagnostic and Statistical Manual for Mental Disorders","author":"American Psychiatric Association","year":"1994"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1054-139X(03)00326-4"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-0720"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/1054-139X(95)00069-5"},{"issue":"1","key":"e_1_2_10_10_2","first-page":"25","article-title":"The outcome of adolescent eating disorders: findings from the Victorian Adolescent Health Cohort Study","volume":"12","author":"Patton GC","year":"2003","journal-title":"Eur J Child Adolesc Psychiatry"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.159.8.1284"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1054-139X(02)00342-7"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1515\/JPEM.2001.14.5.459"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpag.2004.01.003"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-200204000-00016"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-133-10-200011210-00011"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2007.06.010"},{"key":"e_1_2_10_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650071215"},{"key":"e_1_2_10_19_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.165.5.561"},{"key":"e_1_2_10_20_2","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1001\/jama.1991.03460090081037","article-title":"The clinical course of osteoporosis in anorexia nervosa","volume":"265","author":"Rigotti NA","year":"1991","journal-title":"JAMA"},{"key":"e_1_2_10_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(11)63994-3"},{"key":"e_1_2_10_22_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp050187"},{"key":"e_1_2_10_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000148265.90984.c3"},{"key":"e_1_2_10_24_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-1251"},{"key":"e_1_2_10_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/35051587"},{"key":"e_1_2_10_26_2","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1440645"},{"key":"e_1_2_10_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(02)03221-1"},{"key":"e_1_2_10_28_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-1878"},{"key":"e_1_2_10_29_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-2304"},{"key":"e_1_2_10_30_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00615.2004"},{"key":"e_1_2_10_31_2","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1470275"},{"key":"e_1_2_10_32_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-031861"},{"key":"e_1_2_10_33_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.85.12.7167"},{"key":"e_1_2_10_34_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2004.02011.x"},{"key":"e_1_2_10_35_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-0353"},{"key":"e_1_2_10_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4000478"},{"key":"e_1_2_10_37_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1997.02170380020003"},{"key":"e_1_2_10_38_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-1659"},{"key":"e_1_2_10_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-1781(03)00074-X"},{"key":"e_1_2_10_40_2","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1111\/j.1651-2227.2004.tb02628.x","article-title":"Weight requirements for return of menstruation in teenage girls with eating disorders, weight loss and secondary amenorrhoea","author":"Swenne I","year":"2004","journal-title":"Acta Paediatr"},{"key":"e_1_2_10_41_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-032251"},{"key":"e_1_2_10_42_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.185.4155.949"},{"key":"e_1_2_10_43_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-021604"},{"key":"e_1_2_10_44_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1988.tb03708.x"},{"key":"e_1_2_10_45_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.71.3.228"},{"key":"e_1_2_10_46_2","doi-asserted-by":"publisher","DOI":"10.1002\/eat.10087"},{"key":"e_1_2_10_47_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-031326"},{"key":"e_1_2_10_48_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.87.2.500"},{"key":"e_1_2_10_49_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03347473"},{"key":"e_1_2_10_50_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-0723"},{"key":"e_1_2_10_51_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-020256"},{"key":"e_1_2_10_52_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-020545"},{"key":"e_1_2_10_53_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/73.5.865"},{"key":"e_1_2_10_54_2","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-06-0740"},{"key":"e_1_2_10_55_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-200018070-00002"},{"key":"e_1_2_10_56_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-030532"},{"key":"e_1_2_10_57_2","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1210\/jcem.87.5.8628","article-title":"Low dose leptin administration reverses effects of sustained weight\u2010reduction on energy expenditure and circulating concentrations of thyroid hormones","volume":"87","author":"Rosenbaum M","year":"2002","journal-title":"J Clin Metab"},{"key":"e_1_2_10_58_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2004.053553"},{"key":"e_1_2_10_59_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117034"},{"key":"e_1_2_10_60_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.75.4.1060"},{"key":"e_1_2_10_61_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-1043"},{"key":"e_1_2_10_62_2","first-page":"1065","article-title":"Bone density determinants in elderly women: a twin study","volume":"9","author":"Flicker L","year":"1995","journal-title":"J Bone Miner Res"},{"key":"e_1_2_10_63_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa013444"},{"key":"e_1_2_10_64_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjsm.2005.020065"},{"key":"e_1_2_10_65_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-031985"},{"key":"e_1_2_10_66_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001980170061"},{"key":"e_1_2_10_67_2","first-page":"1","article-title":"Assessment of fracture risk and its application to screening for postmenopausal osteoporosis","volume":"843","author":"WHO Study Group","year":"1994","journal-title":"World Health Organ Tech Rep Ser"},{"key":"e_1_2_10_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(00)00353-7"},{"key":"e_1_2_10_69_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.81.4.1586"},{"key":"e_1_2_10_70_2","doi-asserted-by":"crossref","first-page":"3177","DOI":"10.1210\/jcem.85.9.6796","article-title":"Bone size and volumetric density in women with anorexia nervosa receiving estrogen replacement therapy and in women recovering from anorexia nervosa","volume":"85","author":"Karlsson MK","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"e_1_2_10_71_2","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.1999.14.10.1664"},{"key":"e_1_2_10_72_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mop.0000138679.70932.90"},{"key":"e_1_2_10_73_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.88.9.795"},{"key":"e_1_2_10_74_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.86.10.7960"},{"key":"e_1_2_10_75_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI7060"},{"key":"e_1_2_10_76_2","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2000.15.11.2259"},{"key":"e_1_2_10_77_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001703-200310000-00005"},{"key":"e_1_2_10_78_2","doi-asserted-by":"publisher","DOI":"10.1002\/eat.1081"},{"key":"e_1_2_10_79_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-004-1759-2"},{"key":"e_1_2_10_80_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-200011000-00010"},{"key":"e_1_2_10_81_2","doi-asserted-by":"crossref","first-page":"5227","DOI":"10.1210\/jcem.86.11.8050","article-title":"Osteoporosis in eating disorders: a follow\u2010up study of patients with anorexia and bulimia nervosa","volume":"86","author":"Zipfel S","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"e_1_2_10_82_2","first-page":"5227","article-title":"Factors predictive of bone mineral density in eating disordered women: a longitudinal study","volume":"86","author":"Backer D","year":"2000","journal-title":"Int J Eat Disord"},{"key":"e_1_2_10_83_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-0026"},{"key":"e_1_2_10_84_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2001-011889"},{"key":"e_1_2_10_85_2","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmg017"},{"key":"e_1_2_10_86_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-005-0063-0"},{"key":"e_1_2_10_87_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-0512"},{"key":"e_1_2_10_88_2","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2002.125003"},{"key":"e_1_2_10_89_2","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.1999.14.1.136"},{"key":"e_1_2_10_90_2","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2003.18.8.1539"},{"key":"e_1_2_10_91_2","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(01)00677-9"},{"key":"e_1_2_10_92_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-030088"},{"key":"e_1_2_10_93_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-4889(03)00042-9"},{"key":"e_1_2_10_94_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650070204"},{"key":"e_1_2_10_95_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.76.1.9"},{"key":"e_1_2_10_96_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03339746"},{"key":"e_1_2_10_97_2","doi-asserted-by":"publisher","DOI":"10.1385\/JCD:6:1:7"},{"key":"e_1_2_10_98_2","unstructured":"JonesG BoonP.Which bone mass measures discriminate adolescents who have fractured from those who have not?Osteoporos Int23 Aug 2007 [E\u2010pub ahead of print]. doi:10.1007\/s00198\u2010007\u20100458\u20101."},{"key":"e_1_2_10_99_2","doi-asserted-by":"publisher","DOI":"10.1002\/eat.20131"},{"key":"e_1_2_10_100_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1083-3188(02)00145-6"},{"key":"e_1_2_10_101_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1043-2760(00)00336-2"},{"key":"e_1_2_10_102_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-68-3-548"},{"key":"e_1_2_10_103_2","doi-asserted-by":"publisher","DOI":"10.1515\/JPEM.2005.18.9.897"},{"key":"e_1_2_10_104_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2000.tb01879.x"},{"key":"e_1_2_10_105_2","doi-asserted-by":"crossref","first-page":"2403","DOI":"10.1001\/jama.1992.03490170075028","article-title":"Bone gain in adult young women","volume":"268","author":"Recker RR","year":"1992","journal-title":"JAMA"},{"key":"e_1_2_10_106_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)06342-5"},{"key":"e_1_2_10_107_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-005-1867-7"},{"key":"e_1_2_10_108_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI29449"},{"key":"e_1_2_10_109_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/84.1.18"},{"key":"e_1_2_10_110_2","unstructured":"Standing Committee on the Scientific Evaluation of Dietary Reference Intakes Food and Nutrition Board Institute of Medicine.Dietary reference intakes for calcium phosphorus magnesium vitamin D and fluoride. Washington DC:National Academy Press;1997."},{"key":"e_1_2_10_111_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra070553"},{"key":"e_1_2_10_112_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-004-1830-z"},{"key":"e_1_2_10_113_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.80.3.898"},{"key":"e_1_2_10_114_2","doi-asserted-by":"crossref","first-page":"2883","DOI":"10.1210\/jcem.87.6.8574","article-title":"Effects of recombinant human IGF\u20101 and oral contraceptive administration on bone density in anorexia nervosa","volume":"87","author":"Grinspoon S","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"e_1_2_10_115_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1083-3188(00)00082-6"},{"key":"e_1_2_10_116_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001980200123"},{"key":"e_1_2_10_117_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-1181"},{"key":"e_1_2_10_118_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.81.11.3864"},{"key":"e_1_2_10_119_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1754.2003.00083.x"},{"key":"e_1_2_10_120_2","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2002.128207"},{"key":"e_1_2_10_121_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-2548"},{"key":"e_1_2_10_122_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-031885"},{"key":"e_1_2_10_123_2","doi-asserted-by":"publisher","DOI":"10.2165\/00024677-200302060-00005"}],"container-title":["BJOG: An International Journal of Obstetrics &amp; Gynaecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1471-0528.2007.01601.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1471-0528.2007.01601.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T03:22:12Z","timestamp":1708485732000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/j.1471-0528.2007.01601.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1,8]]},"references-count":122,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,2]]}},"alternative-id":["10.1111\/j.1471-0528.2007.01601.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1471-0528.2007.01601.x","archive":["Portico"],"relation":{},"ISSN":["1470-0328","1471-0528"],"issn-type":[{"value":"1470-0328","type":"print"},{"value":"1471-0528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,1,8]]},"assertion":[{"value":"2008-01-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}