{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T21:31:58Z","timestamp":1762032718202},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2008,2,6]],"date-time":"2008-02-06T00:00:00Z","timestamp":1202256000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2008,3]]},"abstract":"<jats:p><jats:bold>Objective\u2002<\/jats:bold> This study compares quality of life (QOL) and acceptability of medical versus surgical treatment of early pregnancy failure (EPF).<\/jats:p><jats:p><jats:bold>Design\u2002<\/jats:bold> A randomised clinical trial of treatment for EPF compared misoprostol vaginally versus vacuum aspiration (VA).<\/jats:p><jats:p><jats:bold>Setting\u2002<\/jats:bold> A multisite trial at four US Urban University Hospitals.<\/jats:p><jats:p><jats:bold>Population\u2002<\/jats:bold> A total of 652 women with an EPF were randomised to treatment.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Participants completed a daily symptom diary and a questionnaire 2 weeks after treatment.<\/jats:p><jats:p><jats:bold>Main outcome measures\u2002<\/jats:bold> The questionnaire assessment included subscales of the Short Form\u201036 Health Survey Revised for QOL and measures of wellbeing, recovery difficulties, and treatment acceptability.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> The two groups did not differ in mean scores for QOL except bodily pain; medical treatment was associated with higher levels of bodily pain than VA (<jats:italic>P <\/jats:italic>&lt; 0.001). Success of treatment was not related to QOL, but acceptability of the procedure was decreased for medical therapy if unsuccessful (<jats:italic>P <\/jats:italic>= 0.003). Type of treatment was not associated with differences in recovery, and the two groups reported similar acceptability except for cramping (<jats:italic>P <\/jats:italic>= 0.02), bleeding (<jats:italic>P <\/jats:italic>&lt; 0.001), and symptom duration (<jats:italic>P <\/jats:italic>= 0.03).<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Despite reporting greater pain and lower acceptability of treatment\u2010related symptoms, QOL and treatment acceptability were similar for medical and surgical treatment of EPF. 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