{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T19:50:20Z","timestamp":1762458620910},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2008,2,6]],"date-time":"2008-02-06T00:00:00Z","timestamp":1202256000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2008,3]]},"abstract":"<jats:p><jats:bold>Objective\u2002<\/jats:bold> Placental abruption may be a manifestation of acute and chronic inflammatory process. We wanted to assess the association of first\u2010trimester serum C\u2010reactive protein (CRP), <jats:italic>Chlamydia pneumoniae <\/jats:italic>antibodies, <jats:italic>Chlamydia trachomatis <\/jats:italic>antibodies or chlamydial heat\u2010shock protein 60 (CHSP60) antibodies to placental abruption.<\/jats:p><jats:p><jats:bold>Design\u2002<\/jats:bold> Retrospective case\u2013control study.<\/jats:p><jats:p><jats:bold>Setting\u2002<\/jats:bold> University Hospital.<\/jats:p><jats:p><jats:bold>Population\u2002<\/jats:bold> A total of 181 women with subsequent placental abruption and 261 control women with normal pregnancy.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Serum samples collected at first trimester (mean 10.4 gestational weeks) were analysed for CRP levels, <jats:italic>C. pneumoniae<\/jats:italic>\u2010specific immunoglobulin G (IgG) and immunoglobulin A (IgA) antibodies and <jats:italic>C. trachomatis<\/jats:italic>\u2010specific IgG, IgA and CHSP60 antibodies.<\/jats:p><jats:p><jats:bold>Main outcome measure\u2002<\/jats:bold> Placental abruption.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> The levels of CRP showed no difference between the cases and the controls (median 2.35 mg\/l [interquartile range {IQR} 1.09\u20135.93] versus 2.28 mg\/l [IQR 0.92\u20135.01], not significant). <jats:italic>C. pneumoniae<\/jats:italic>\u2010specific IgG and IgA as well as <jats:italic>C. trachomatis<\/jats:italic>\u2010specific IgG, IgA and CHSP60 antibody frequencies were similar between the groups. There was no association between CRP levels and chlamydial antibodies.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> These markers of inflammation in early pregnancy failed to predict subsequent placental abruption.<\/jats:p>","DOI":"10.1111\/j.1471-0528.2007.01663.x","type":"journal-article","created":{"date-parts":[[2008,2,6]],"date-time":"2008-02-06T12:17:33Z","timestamp":1202300253000},"page":"486-491","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Prediction of placental abruption by testing for C\u2010reactive protein and chlamydial antibody levels in early 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