{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T21:43:58Z","timestamp":1789940638294,"version":"4.0.1"},"reference-count":54,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2009,2,4]],"date-time":"2009-02-04T00:00:00Z","timestamp":1233705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2009,4]]},"abstract":"<jats:p><jats:bold>Background\u2002<\/jats:bold> Rates of labour induction are increasing.<\/jats:p><jats:p><jats:bold>Objectives\u2002<\/jats:bold> To review the evidence supporting indications for induction.<\/jats:p><jats:p><jats:bold>Search strategy\u2002<\/jats:bold> We listed indications for labour induction and then reviewed the evidence. We searched MEDLINE and the Cochrane Library between 1980 and April 2008 using several terms and combinations, including induction of labour, premature rupture of membranes, post\u2010term pregnancy, preterm prelabour rupture of membranes (PROM), multiple gestation, suspected macrosomia, diabetes, gestational diabetes mellitus, cardiac disease, fetal anomalies, systemic lupus erythematosis, oligohydramnios, alloimmunization, rhesus disease, intrahepatic cholestasis of pregnancy (IHCP), and intrauterine growth restriction (IUGR). We performed a review of the literature supporting each indication.<\/jats:p><jats:p><jats:bold>Selection criteria\u2002<\/jats:bold> We identified 1387 abstracts and reviewed 418 full text articles. We preferentially included high\u2010quality systematic reviews or large randomised trials. Where no such studies existed, we included the best evidence available from smaller randomised trials and observational studies.<\/jats:p><jats:p><jats:bold>Main results\u2002<\/jats:bold> We included 34 full text articles. For each indication, we assigned levels of evidence and grades of recommendation based upon the GRADE system. Recommendations for induction of labour for post\u2010term gestation, PROM at term, and premature rupture of membranes near term with pulmonary maturity are supported by the evidence. Induction for IUGR before term reduces intrauterine fetal death, but increases caesarean deliveries and neonatal deaths. Evidence is insufficient to support induction for women with insulin\u2010requiring diabetes, twin gestation, fetal macrosomia, oligohydramnios, cholestasis of pregnancy, maternal cardiac disease and fetal gastroschisis.<\/jats:p><jats:p><jats:bold>Authors\u2019 conclusions\u2002<\/jats:bold> Research is needed to determine risks and benefits of induction for many commonly advocated clinical indications.<\/jats:p>","DOI":"10.1111\/j.1471-0528.2008.02065.x","type":"journal-article","created":{"date-parts":[[2009,2,4]],"date-time":"2009-02-04T10:26:49Z","timestamp":1233743209000},"page":"626-636","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":127,"title":["Indications for induction of labour: a best\u2010evidence review"],"prefix":"10.1111","volume":"116","author":[{"given":"E","family":"Mozurkewich","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Chilimigras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Koepke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Keeton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"VJ","family":"King","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,3,11]]},"reference":[{"key":"e_1_2_6_2_2","article-title":"Births: final data for 2005","volume":"56","author":"Martin JA","year":"2007","journal-title":"Natl Vital Stat Rep"},{"key":"e_1_2_6_3_2","volume-title":"Listening to Mothers II: Report of the Second National US Survey of Women\u2019s Childbearing Experiences","author":"Declercq ER","year":"2006"},{"key":"e_1_2_6_4_2","unstructured":"Anonymous.BMJ clinical evidence systematic reviews.2007[http:\/\/clinicalevidence.bmj.com\/ceweb\/about\/systematic_reviews.jsp]. 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