{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T15:55:35Z","timestamp":1765727735166},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,7,27]],"date-time":"2011-07-27T00:00:00Z","timestamp":1311724800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:p><jats:italic>Please cite this paper as:<\/jats:italic> Reilly R, Paranjothy S, Beer H, Brooks C, Fielder H, Lyons R. Birth outcomes following treatment for precancerous changes to the cervix: a population\u2010based record linkage study. BJOG 2012;119:236\u2013244.<\/jats:p><jats:p><jats:bold>Objective\u2002<\/jats:bold> To examine whether treatments for precancerous changes to the cervix are associated with adverse birth outcomes in subsequent pregnancies.<\/jats:p><jats:p><jats:bold>Design\u2002<\/jats:bold> Population\u2010based retrospective cohort study using electronic linkage of data from the Welsh cervical screening programme and a national routine child health database.<\/jats:p><jats:p><jats:bold>Setting\u2002<\/jats:bold> Wales.<\/jats:p><jats:p><jats:bold>Population\u2002<\/jats:bold> A total of 174\u2003325 women aged 20\u201339\u2003years who received cervical screening between April 2001 and March 2004.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Logistic regression was used to compare the odds of each birth outcome between women who had negative cervical smears and women who received either colposcopy\u2003\u00b1\u2003punch biopsy only or colposcopy and excisional or ablative treatments, adjusted for confounding factors (e.g. age, social deprivation and smoking).<\/jats:p><jats:p><jats:bold>Main outcome measures\u2002<\/jats:bold> Preterm birth (before 37, 32 and 28\u2003weeks of gestation), and low birthweight (&lt;2500\u2003g).<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Compared with women who had negative cervical smears, the odds ratio for preterm birth (&lt;37\u2003weeks) was significantly increased in women who had colposcopy only (adjusted odds ratio 1.54, 95% CI 1.32\u20131.80) and single excisional treatment (adjusted odds ratio 1.77, 95% CI 1.47\u20132.13). Similar results were observed for preterm birth at &lt;32\u2003weeks of gestation. There was no increased risk of preterm birth or low birthweight for women who had treatment compared with women who had colposcopy only.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> Women who were referred for colposcopy had an increased risk of preterm births regardless of whether or not they received treatment to the cervix. This increased risk could be the result of common risk factors for abnormal smears and preterm birth.<\/jats:p>","DOI":"10.1111\/j.1471-0528.2011.03052.x","type":"journal-article","created":{"date-parts":[[2011,7,27]],"date-time":"2011-07-27T07:51:27Z","timestamp":1311753087000},"page":"236-244","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Birth outcomes following treatment for precancerous changes to the cervix: a population\u2010based record linkage study"],"prefix":"10.1111","volume":"119","author":[{"given":"R","family":"Reilly","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Paranjothy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Beer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CJ","family":"Brooks","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HM","family":"Fielder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RA","family":"Lyons","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,7,27]]},"reference":[{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1996.196"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16674-9"},{"key":"e_1_2_10_4_2","volume-title":"Criteria for Appraising the Viability, Effectiveness and Appropriateness of a Screening Programme","author":"National Screening Committee","year":"2009"},{"key":"e_1_2_10_5_2","volume-title":"Births and Deaths in England and Wales 2009","author":"Office for National Statistics","year":"2010"},{"key":"e_1_2_10_6_2","volume-title":"The Impact of Cervical Screening on Young Women: A Critical Review of the Literature 2002\u20132009","author":"Sasieni P","year":"2010"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2006.01107.x"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.291.17.2100"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000251497.55065.74"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.a1343"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000151991.09124.bb"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1080\/01443610310001620242"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68181-6"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.a1284"},{"key":"e_1_2_10_15_2","volume-title":"Births in Wales 2007: Data from the National Community Child Health Database","author":"Welsh Assembly Government","year":"2008"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6963-9-157"},{"key":"e_1_2_10_17_2","volume-title":"Annual Report 2008","author":"All Wales Perinatal Survey","year":"2009"},{"key":"e_1_2_10_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000253239.87040.23"},{"key":"e_1_2_10_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181b5cba3"},{"key":"e_1_2_10_20_2","first-page":"1509","article-title":"Screening for cervical cancer: a review of women\u2019s attitudes, knowledge and behaviour","volume":"48","author":"Fylan F","year":"1998","journal-title":"Br J Gen Pract"},{"key":"e_1_2_10_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2025"},{"key":"e_1_2_10_22_2","doi-asserted-by":"publisher","DOI":"10.1515\/JPM.2007.001"},{"key":"e_1_2_10_23_2","volume-title":"Welsh Index of Multiple Deprivation 2005 Summary Report","author":"Welsh Assembly Government","year":"2005"}],"container-title":["BJOG: An International Journal of Obstetrics &amp; 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