{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:24:45Z","timestamp":1787167485602,"version":"build-2736575974"},"reference-count":64,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,10,19]],"date-time":"2011-10-19T00:00:00Z","timestamp":1318982400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:p>\n                    <jats:italic>Please cite this paper as:<\/jats:italic>\n                    Hunter M, Gentry\u2010Maharaj A, Ryan A, Burnell M, Lanceley A, Fraser L, Jacobs I, Menon U. Prevalence, frequency and problem rating of hot flushes persist in older postmenopausal women: impact of age, body mass index, hysterectomy, hormone therapy use, lifestyle and mood in a cross\u2010sectional cohort study of 10\u2003418 British women aged 54\u201365. BJOG 2012;119:40\u201350.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Objective\u2002<\/jats:bold>\n                    Hot flushes and night sweats (HFs\/NSs) are the main menopausal symptoms, but few studies have been adequately powered to examine the dimensions or predictors of experiencing HFs\/NSs. We report on these variables in a large UK cohort of postmenopausal women.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Design\u2002<\/jats:bold>\n                    Cross\u2010sectional cohort study.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Setting\u2002<\/jats:bold>\n                    UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS) cohort.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Population\u2002<\/jats:bold>\n                    A cohort of 202\u2003638 postmenopausal women, aged 50\u201374\u2003years, without oophorectomy, recruited to UKCTOCS between 2001 and 2005.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods\u2002<\/jats:bold>\n                    Women completed a follow\u2010up questionnaire, and those aged 54\u201365\u2003years were mailed a survey in July 2008.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Main outcome measures\u2002<\/jats:bold>\n                    Hot flush prevalence and hot flush rating scale.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results\u2002<\/jats:bold>\n                    Of the 15\u2003000 women mailed, 10\u2003418 returned completed questionnaires; 90% had previously had HFs\/NSs. Despite being on average 10\u2003years postmenopausal, 54% experienced HFs\/NSs (frequency of 33 per week with mean problem rating 4\/10) that persisted across the age range. Past hysterectomy (OR\u20031.50, 95% CI\u20031.19\u20131.86), ever having smoked (OR\u20031.27, 95% CI\u20031.11\u20131.46) and alcohol consumption (current units) (OR\u20031.05, 95% CI\u20031.01\u20131.09) predicted ever having had HFs\/NSs. Anxiety (OR\u20033.09, 95% CI\u20032.57\u20133.72), hysterectomy (OR\u20032.74, 95% CI\u20032.32\u20133.25), depressed mood (OR\u20031.57, 95% CI\u20031.24\u20131.99), years since last menstrual period (OR\u20030.95, 95% CI\u20030.94\u20130.96) and education (above and below 18\u2003years) (OR\u20030.98, 95% CI\u20030.97\u20130.99) predicted the current prevalence of HFs\/NSs. Few predictors of frequency were identified, but problem rating was associated with depressed mood, hysterectomy, skirt size increase and frequency of HFs\/NSs. Past hormone therapy users who had discontinued treatment were more likely to have HFs\/NSs that were more frequent and problematic.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions\u2002<\/jats:bold>\n                    To date, this is the largest UK study of the experience of HFs\/NSs amongst older postmenopausal women. HFs\/NSs are more prevalent in this age band than has previously been assumed. These findings and the associations of smoking, hysterectomy, anxiety, depressed mood and hormone therapy use with the experience of HFs\/NSs have implications for prevention and symptom management.\n                  <\/jats:p>","DOI":"10.1111\/j.1471-0528.2011.03166.x","type":"journal-article","created":{"date-parts":[[2011,10,14]],"date-time":"2011-10-14T08:26:51Z","timestamp":1318580811000},"page":"40-50","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":124,"title":["Prevalence, frequency and problem rating of hot flushes persist in older postmenopausal women: impact of age, body mass index, hysterectomy, hormone therapy use, lifestyle and mood in a cross\u2010sectional cohort study of 10\u2003418 British women aged 54\u201365"],"prefix":"10.1111","volume":"119","author":[{"given":"MS","family":"Hunter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Gentry\u2010Maharaj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Ryan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Burnell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Lanceley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Fraser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Jacobs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U","family":"Menon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,10,19]]},"reference":[{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1080\/13697130601181486"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1080\/13697130802556296"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1080\/cmt.4.4.267.272"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(89)90044-9"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a116936"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1258\/136218006777525721"},{"key":"e_1_2_11_8_2","first-page":"41","article-title":"Age and symptomatology of menopause in Karachi, Pakistan","volume":"3","author":"Adhi M","year":"2007","journal-title":"Pak J Physiol"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/gme.0b013e31818d414e"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1990.tb30316.x"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.3122\/jabfm.2010.01.090052"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/gme.0b013e3181a3cdaf"},{"key":"e_1_2_11_13_2","first-page":"321e33","article-title":"Risks and benefits of oestrogen plus progestin in healthy postmenopausal women: principal results from the Women\u2019s health initiative randomised controlled trial","volume":"288","author":"Rossouw JE","year":"2002","journal-title":"JAMA"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa030808"},{"key":"e_1_2_11_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.gme.0000243569.70946.9d"},{"key":"e_1_2_11_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2005.09.051"},{"key":"e_1_2_11_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2006.11.001"},{"key":"e_1_2_11_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0885-3924(01)00353-0"},{"key":"e_1_2_11_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.2044-8260.1995.tb01493.x"},{"key":"e_1_2_11_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/gme.0b013e3181591db7"},{"key":"e_1_2_11_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/gme.0b013e318204a1fb"},{"key":"e_1_2_11_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2010.04.005"},{"key":"e_1_2_11_23_2","doi-asserted-by":"publisher","DOI":"10.3109\/13697131003717070"},{"key":"e_1_2_11_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61400-8"},{"key":"e_1_2_11_25_2","unstructured":"DarziA.High quality care for all: NHS next stage review final report. 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