{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T17:12:19Z","timestamp":1770484339601,"version":"3.49.0"},"reference-count":63,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,5,10]],"date-time":"2012-05-10T00:00:00Z","timestamp":1336608000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:p><jats:italic>Please cite this paper as:<\/jats:italic>Deraco M, Virz\u00ec S, Raspagliesi F, Iusco D, Puccio F, Macr\u00ec A, Famulari C, Solazzo M, Bonomi S, Grassi A, Baratti D, Kusamura S. Secondary cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for recurrent epithelial ovarian cancer: a multi\u2010institutional study. BJOG 2012;119:800\u2013809.<\/jats:p><jats:p><jats:bold>Objective\u2002<\/jats:bold>To assess the efficacy and morbidity and mortality of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) in recurrent epithelial ovarian cancer (EOC).<\/jats:p><jats:p><jats:bold>Design\u2002<\/jats:bold>A retrospective study conducted using information extracted from a multi\u2010institutional prospective database on peritoneal surface malignancies (PSMs).<\/jats:p><jats:p>Setting Four Italian centres specializing in locoregional treatment of PSM.<\/jats:p><jats:p><jats:bold>Population\u2002<\/jats:bold>Patients with recurrent EOC.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold>Fifty\u2010six patients underwent 57 combined procedures. CRS was performed using peritonectomy procedures and HIPEC using the closed\u2010abdomen technique with cisplatin and doxorubicin or cisplatin and mitomycin\u2010C.<\/jats:p><jats:p><jats:bold>Main outcome measures\u2002<\/jats:bold>Overall survival (OS), progression\u2010free survival (PFS), morbidity and mortality rates.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold>The median age of the patients was 55.2\u2003years (range 30\u201375\u2003years). The median peritoneal cancer index was 15.2 (range 4\u201330). Forty\u2010seven patients had microscopic residual disease (completeness of cytoreduction, CC\u20100), seven had residual disease \u22642.5\u2003mm (CC\u20101) and one had residual disease &gt;2.5\u2003mm (CC&gt;2). Major complications occurred in 15 patients (26.3%), and procedure\u2010related mortality occurred in three patients (5.3%). The median follow\u2010up time was 23.1\u2003months. The median OS and PFS were 25.7 (95% CI 20.3\u201331.0) and 10.8 (95% CI 5.4\u201316.2) months, respectively. The 5\u2010year OS and PFS were 23% and 7%, respectively. Independent prognostic factors affecting OS according to the multivariate analysis were Eastern Cooperative Oncology Group performance status, preoperative serum albumin, and completeness of cytoreduction.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold>Patients with recurrent EOC treated with CRS and HIPEC showed promising results in terms of outcome. The combined treatment strategy could benefit subsets of patients wider than that defined for conventional secondary debulking surgery without HIPEC. These data warrant further evaluation in randomised clinical trials.<\/jats:p>","DOI":"10.1111\/j.1471-0528.2011.03207.x","type":"journal-article","created":{"date-parts":[[2012,5,10]],"date-time":"2012-05-10T10:25:14Z","timestamp":1336645514000},"page":"800-809","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Secondary cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for recurrent epithelial ovarian cancer: a multi\u2010institutional study"],"prefix":"10.1111","volume":"119","author":[{"given":"M","family":"Deraco","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Virz\u00ec","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DR","family":"Iusco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Puccio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Macr\u00ec","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Famulari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Solazzo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Bonomi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Grassi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Baratti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Kusamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,5,10]]},"reference":[{"key":"e_1_2_9_2_2","first-page":"517","article-title":"Ovarian cancer. 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