{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T05:38:13Z","timestamp":1791437893455,"version":"4.3.3"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,2,10]],"date-time":"2012-02-10T00:00:00Z","timestamp":1328832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:p><jats:italic>Please cite this paper as:<\/jats:italic> Memmo A, Dias T, Mahsud\u2010Dornan S, Papageorghiou A, Bhide A, Thilaganathan B. Prediction of selective fetal growth restriction and twin\u2010to\u2010twin transfusion syndrome in monochorionic twins. BJOG 2012;119:417\u2013421.<\/jats:p><jats:p><jats:bold>Objective\u2002<\/jats:bold> To study the correlation of discrepancy between crown\u2013rump length (CRL) and nuchal translucency (NT) in monochorionic twins at 11\u201314\u2003weeks of gestation and subsequent development of twin\u2010to\u2010twin transfusion syndrome (TTTS) and selective fetal growth restriction (sFGR).<\/jats:p><jats:p><jats:bold>Design\u2002<\/jats:bold> Retrospective cohort study.<\/jats:p><jats:p><jats:bold>Setting\u2002<\/jats:bold> Tertiary\u2010care Fetal Medicine Unit, London.<\/jats:p><jats:p><jats:bold>Sample\u2002<\/jats:bold> Monochorionic twin pregnancies with known outcome.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Inter\u2010twin discrepancy was calculated as a percentage of the larger CRL and smaller NT and compared among those developing TTTS, those with sFGR and those with normal outcome. Receiver operating characteristic (ROC) curves were constructed to evaluate the performance of inter\u2010twin discrepancy in prediction of sFGR and TTTS.<\/jats:p><jats:p><jats:bold>Main outcome measures\u2002<\/jats:bold> Development of TTTS and sFGR.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> A total of 242 monochorionic twin pregnancies were studied (102 TTTS, 36 sFGR and 104 controls). The median CRL discrepancy in the sFGR group (11.9%) was significantly higher (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001) than in the TTTS group (3.8%) and control group (3.5%). Median inter\u2010twin NT discrepancies were not significantly different (<jats:italic>P<\/jats:italic>\u2003=\u20030.869) between sFGR and both TTTS and control groups (15.6%, 16.7% and 14.8%, respectively). Discrepancy in CRL performs well as a screening test for sFGR (area under ROC curve =\u20030.89), but not for TTTS (area under ROC curve =\u20030.58).<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> First\u2010trimester CRL discrepancy in monochorionic twins is a marker for subsequent development of sFGR rather than TTTS. Inter\u2010twin NT discrepancy does not appear to be significantly different in these two groups from those with normal outcome.<\/jats:p>","DOI":"10.1111\/j.1471-0528.2011.03250.x","type":"journal-article","created":{"date-parts":[[2012,2,10]],"date-time":"2012-02-10T23:01:53Z","timestamp":1328914913000},"page":"417-421","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Prediction of selective fetal growth restriction and twin\u2010to\u2010twin transfusion syndrome in monochorionic twins"],"prefix":"10.1111","volume":"119","author":[{"given":"A","family":"Memmo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Dias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Mahsud\u2010Dornan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AT","family":"Papageorghiou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Bhide","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Thilaganathan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,2,10]]},"reference":[{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1997.tb10948.x"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2006.01.015"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2010.07.002"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032597"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2008.04.022"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2008.04.005"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.4006"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.3918"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7533"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1996.07060421.x"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2010.02592.x"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7200292"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7566"},{"key":"e_1_2_11_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7612"},{"key":"e_1_2_11_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.4046"},{"key":"e_1_2_11_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.6396"},{"key":"e_1_2_11_18_2","doi-asserted-by":"publisher","DOI":"10.4038\/cmj.v55i3.2291"},{"key":"e_1_2_11_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2008.03.050"},{"key":"e_1_2_11_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2007.01336.x"},{"key":"e_1_2_11_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2007.08.004"},{"key":"e_1_2_11_22_2","doi-asserted-by":"publisher","DOI":"10.1067\/S0002-9378(03)00714-2"},{"key":"e_1_2_11_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.1966"},{"key":"e_1_2_11_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.6422"},{"key":"e_1_2_11_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1802"},{"key":"e_1_2_11_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2010.09.375"},{"key":"e_1_2_11_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.8802"},{"key":"e_1_2_11_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2009.05.001"},{"key":"e_1_2_11_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7515"}],"container-title":["BJOG: An International Journal of Obstetrics &amp; 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