{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T23:17:27Z","timestamp":1785799047296,"version":"3.56.0"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,2,3]],"date-time":"2012-02-03T00:00:00Z","timestamp":1328227200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:p><jats:italic>Please cite this paper as:<\/jats:italic> Persson M, Pasupathy D, Hanson U, Norman M. Disproportionate body composition and perinatal outcome in large<jats:italic>\u2010<\/jats:italic>for<jats:italic>\u2010<\/jats:italic>gestational<jats:italic>\u2010<\/jats:italic>age infants to mothers with type 1 diabetes. BJOG 2012;119:565\u2013572.<\/jats:p><jats:p><jats:bold>Objective\u2002<\/jats:bold> To determine if disproportionate body composition is a risk factor for perinatal complications in large\u2010for\u2010gestational\u2010age infants born to mothers with type 1 diabetes.<\/jats:p><jats:p><jats:bold>Design\u2002<\/jats:bold> Population\u2010based cohort study.<\/jats:p><jats:p><jats:bold>Setting\u00a0<\/jats:bold> Data from the Swedish Medical Birth Registry from 1998 to 2007.<\/jats:p><jats:p><jats:bold>Population\u2002<\/jats:bold> National cohort of 3517 infants born to mothers with type 1 diabetes. Only singletons with gestational age 32\u201343\u2003weeks were included.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Large for gestational age (LGA) was defined as birthweight &gt;\u200390th centile and appropriate for gestational age (AGA) as birthweight between 10th and 90th centiles. Disproportionate (D) infants were defined as having a ponderal index [PI: calculated as birthweight in grams\/(length in cm)\u00b3 &gt;\u200390th centile] and proportionate (P) as PI\u2003\u2264\u200390th centile. LGA infants were classified as P\u2010LGA or D\u2010LGA. Odds ratios were calculated for D\u2010LGA and P\u2010LGA infants, with AGA infants as the reference category. Odds ratios were adjusted for mode of delivery, fetal distress and stratified by gestational age.<\/jats:p><jats:p><jats:bold>Main outcome measures\u2002<\/jats:bold> The primary outcome was a composite of neonatal morbidities, i.e. any of the following diagnoses: Apgar score &lt;\u20037 at 5\u2003minutes, birth trauma (Erb\u2019s palsy or clavicle fracture), respiratory disorder, hyperbilirubinaemia or hypoglycaemia requiring treatment.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Composite morbidity was significantly more frequent in LGA as opposed to AGA infants, but there was no difference in risk between P\u2010LGA and D\u2010LGA infants.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> High birthweight, irrespective of body proportionality, is a risk factor for neonatal complications in offspring of women with type 1 diabetes.<\/jats:p>","DOI":"10.1111\/j.1471-0528.2012.03277.x","type":"journal-article","created":{"date-parts":[[2012,2,3]],"date-time":"2012-02-03T13:55:27Z","timestamp":1328277327000},"page":"565-572","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Disproportionate body composition and perinatal outcome in large<i>\u2010<\/i>for<i>\u2010<\/i>gestational<i>\u2010<\/i>age infants to mothers with type 1 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