{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T00:50:28Z","timestamp":1771548628276,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,6,13]],"date-time":"2012-06-13T00:00:00Z","timestamp":1339545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:p><jats:italic>Please cite this paper as:<\/jats:italic> Dodd J, Crowther C, Haslam R, Robinson J. Elective birth at 37\u2003weeks of gestation versus standard care for women with an uncomplicated twin pregnancy at term: the Twins Timing of Birth Randomised Trial. BJOG 2012;119:964\u2013974.<\/jats:p><jats:p><jats:bold>Objective\u2002<\/jats:bold> To evaluate whether for women with an uncomplicated twin pregnancy, elective birth at 37\u2003weeks of gestation was associated with reduced risk of death or serious outcomes for babies, without increasing harm.<\/jats:p><jats:p><jats:bold>Design\u2002<\/jats:bold> Randomised controlled trial.<\/jats:p><jats:p><jats:bold>Setting\u2002<\/jats:bold> Maternity hospitals across Australia, New Zealand and Italy.<\/jats:p><jats:p><jats:bold>Population\u2002<\/jats:bold> A total of 235 women with an uncomplicated twin pregnancy at 36<jats:sup>+6<\/jats:sup>\u2003weeks of gestation, with no contraindication to continuing their pregnancy.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Using a computer\u2010generated, central telephone randomisation service, 235 women were randomised to Elective Birth (birth at 37\u2003weeks; <jats:italic>n\u2003<\/jats:italic>=\u2003116) or Standard Care (continued expectant management, with birth planned from 38\u2003weeks; <jats:italic>n<\/jats:italic>\u2003=\u2003119). Outcome assessors were masked to treatment allocation.<\/jats:p><jats:p><jats:bold>Main outcome measure\u2002<\/jats:bold> A composite of serious adverse outcome for the infant.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> For women with an uncomplicated twin pregnancy, elective birth at 37\u2003weeks of gestation was associated with a significant reduction in risk of serious adverse outcome for the infant (Elective Birth 11\/232 [4.7%] versus Standard Care 29\/238 [12.2%]; risk ratio [RR] 0.39; 95% CI 0.20\u20130.75; <jats:italic>P<\/jats:italic>\u2003=\u20030.005), reflecting a reduction in birthweight less than the third centile using singleton gestational age\u2010specific charts (Elective Birth 7\/232 [3.0%] versus Standard Care 24\/238 [10.1%]; RR 0.30; 95% CI 0.13\u20130.67; <jats:italic>P<\/jats:italic>\u2003=\u20030.004). In a <jats:italic>post hoc<\/jats:italic> analysis using twin gestational age\u2010specific charts, there was evidence of a trend towards a reduction in the primary composite of serious adverse infant outcome (Elective Birth Group 4\/232 [1.7%] versus Standard Care Group 12\/238 [5.0%]; RR 0.34; 95% CI 0.11 to 1.05; <jats:italic>P\u2003<\/jats:italic>=\u20030.06).<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> The findings of our study support recommendations for women with an uncomplicated twin pregnancy to birth at 37\u2003weeks of gestation.<\/jats:p>","DOI":"10.1111\/j.1471-0528.2012.03356.x","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T03:58:32Z","timestamp":1339473512000},"page":"964-974","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Elective birth at 37\u2003weeks of gestation versus standard care for women with an uncomplicated twin pregnancy at term: 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