{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T11:09:25Z","timestamp":1770721765079,"version":"3.49.0"},"reference-count":14,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2012,6,18]],"date-time":"2012-06-18T00:00:00Z","timestamp":1339977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:p><jats:italic>Please cite this paper as:<\/jats:italic> Tajik P, van der Tuuk K, Koopmans C, Groen H, van Pampus M, van der Berg P, van der Post J, van Loon A, de Groot C, Kwee A, Huisjes A, van Beek E, Papatsonis D, Bloemenkamp K, van Unnik G, Porath M, Rijnders R, Stigter R, de Boer K, Scheepers H, Zwinderman A, Bossuyt P, Mol B. Should cervical favourability play a role in the decision for labour induction in gestational hypertension or mild pre\u2010eclampsia at term? An exploratory analysis of the HYPITAT trial. BJOG 2012;119:1123\u20131130.<\/jats:p><jats:p><jats:bold>Objective\u2002<\/jats:bold> To examine whether cervical favourability (measured by cervical length and the Bishop score) should inform obstetricians\u2019 decision regarding labour induction for women with gestational hypertension or mild pre\u2010eclampsia at term.<\/jats:p><jats:p><jats:bold>Design\u2002<\/jats:bold> A post hoc analysis of the Hypertension and Pre\u2010eclampsia Intervention Trial At Term (HYPITAT).<\/jats:p><jats:p><jats:bold>Setting\u2002<\/jats:bold> Obstetric departments of six university and 32 teaching and district hospitals in the Netherlands.<\/jats:p><jats:p><jats:bold>Population\u2002<\/jats:bold> A total of 756 women diagnosed with gestational hypertension or pre\u2010eclampsia between 36\u2003+\u20030 and 41\u2003+\u20030\u2003weeks of gestation randomly allocated to induction of labour or expectant management.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Data were analysed using logistic regression modelling.<\/jats:p><jats:p><jats:bold>Main outcome measures\u2002<\/jats:bold> The occurrence of a high\u2010risk maternal situation defined as either maternal complications or progression to severe disease. Secondary outcomes were caesarean delivery and adverse neonatal outcomes.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> The superiority of labour induction in preventing high\u2010risk situations in women with gestational hypertension or mild pre\u2010eclampsia at term varied significantly according to cervical favourability. In women who were managed expectantly, the longer the cervix the higher the risk of developing maternal high\u2010risk situations, whereas in women in whom labour was induced, cervical length was not associated with a higher probability of maternal high\u2010risk situations (test of interaction <jats:italic>P\u2003<\/jats:italic>=\u20030.03). Similarly, the beneficial effect of labour induction on reducing the caesarean section rate was stronger in women with an unfavourable cervix.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> Against widely held opinion, our exploratory analysis showed that women with gestational hypertension or mild pre\u2010eclampsia at term who have an unfavourable cervix benefited more from labour induction than other women.<\/jats:p><jats:p><jats:bold>Trial registration\u2002<\/jats:bold> The trial has been registered in the clinical trial register as ISRCTN08132825.<\/jats:p>","DOI":"10.1111\/j.1471-0528.2012.03405.x","type":"journal-article","created":{"date-parts":[[2012,6,18]],"date-time":"2012-06-18T15:36:48Z","timestamp":1340033808000},"page":"1123-1130","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Should cervical favourability play a role in the decision for labour induction in gestational hypertension or mild pre\u2010eclampsia at term? 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