{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T20:44:37Z","timestamp":1768423477467,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2012,6,27]],"date-time":"2012-06-27T00:00:00Z","timestamp":1340755200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:p><jats:italic>Please cite this paper as:<\/jats:italic> Lee B, Zhang Z, Wikman A, Lindqvist P, Reilly M. ABO and RhD blood groups and gestational hypertensive disorders: a population\u2010based cohort study. BJOG 2012;119:1232\u20131237.<\/jats:p><jats:p><jats:bold>Objective\u2002<\/jats:bold> To examine the association between ABO and RhD blood groups and gestational hypertensive disorders in a large population\u2010based cohort.<\/jats:p><jats:p><jats:bold>Design\u2002<\/jats:bold> Cohort study. Risks of gestational hypertensive disorders, pre\u2010eclampsia, and severe pre\u2010eclampsia, estimated by odds ratios for maternal ABO blood group and RhD status.<\/jats:p><jats:p><jats:bold>Setting\u2002<\/jats:bold> National health registers of Sweden.<\/jats:p><jats:p><jats:bold>Population\u2002<\/jats:bold> All singleton deliveries in Sweden born to first\u2010time mothers during the period 1987\u20132002 [total <jats:italic>n\u2003<\/jats:italic>=\u2003641\u2003926; any gestational hypertensive disorders, <jats:italic>n\u2003<\/jats:italic>=\u200339\u2003011 (6.1%); pre\u2010eclampsia cases, <jats:italic>n\u2003<\/jats:italic>=\u200329\u2003337 (4.6%); severe pre\u2010eclampsia cases, <jats:italic>n\u2003<\/jats:italic>=\u20038477 (1.3%)].<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Using blood group O as a reference, odds ratios of gestational hypertensive disorders, pre\u2010eclampsia, and severe pre\u2010eclampsia were obtained from logistic regression models adjusted for potential confounding factors.<\/jats:p><jats:p><jats:bold>Main outcome measures\u2002<\/jats:bold> Gestational hypertensive disorders, pre\u2010eclampsia, and severe pre\u2010eclampsia.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Compared with blood group O, all non\u2010O blood groups had modest but statistically significantly higher odds of pre\u2010eclampsia. Blood group AB had the highest risk for pre\u2010eclampsia (OR\u2003=\u20031.10, 95% CI 1.04\u20131.16) and severe pre\u2010eclampsia (OR\u2003=\u20031.18, 95% CI 1.07\u20131.30). RhD\u2010positive mothers had a small increased risk for pre\u2010eclampsia (OR\u2003=\u20031.07, 95% CI 1.03\u20131.10).<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> In the largest study on this topic to date, women with AB blood group have the highest risks of gestational hypertensive disorders, pre\u2010eclampsia, and severe pre\u2010eclampsia, whereas women with O blood group have the lowest risks of developing these disorders. Although the magnitude of increased risk is small, this finding may help improve our understanding of the etiology of pre\u2010eclampsia.<\/jats:p>","DOI":"10.1111\/j.1471-0528.2012.03421.x","type":"journal-article","created":{"date-parts":[[2012,6,27]],"date-time":"2012-06-27T16:25:19Z","timestamp":1340814319000},"page":"1232-1237","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["ABO and RhD blood groups and gestational hypertensive disorders: a population\u2010based cohort study"],"prefix":"10.1111","volume":"119","author":[{"given":"BK","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Wikman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PG","family":"Lindqvist","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Reilly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,6,27]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68397-9"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2011.01.006"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1080\/00016340500442449"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2008.20"},{"key":"e_1_2_6_6_2","doi-asserted-by":"crossref","unstructured":"BowyerL.The confidential enquiry into maternal and child health (CEMACH). 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