{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T09:30:59Z","timestamp":1789983059098,"version":"4.0.1"},"reference-count":56,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2012,7,25]],"date-time":"2012-07-25T00:00:00Z","timestamp":1343174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:p><jats:italic>Please cite this paper as:<\/jats:italic> Herraiz S, Pellicer B., Serra V, Cauli O, Cortijo J, Felipo V, Pellicer A. Sildenafil citrate improves perinatal outcome in fetuses from pre\u2010eclamptic rats. BJOG 2012;119:1394\u20131402.<\/jats:p><jats:p><jats:bold>Objective\u2002<\/jats:bold> To evaluate perinatal outcome after sildenafil citrate (SC) administration at the onset of pregnancy in a rat pre\u2010eclampsia model.<\/jats:p><jats:p><jats:bold>Design\u2002<\/jats:bold>  <jats:italic>In vivo<\/jats:italic> animal experimental study.<\/jats:p><jats:p><jats:bold>Setting\u2002<\/jats:bold> Fundaci\u00f3n IVI\u2010Instituto Universitario IVI, Valencia, Spain.<\/jats:p><jats:p><jats:bold>Sample<\/jats:bold> Control and pre\u2010eclampsia\u2010induced pregnant Wistar rats exposed to chronic SC administration.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> We evaluated the use of SC, which was tested as a potential therapeutic tool to maintain vasodilatation in complicated pregnancies. We have demonstrated previously that SC shows a hypotensive selective effect in normal rat pregnancies when compared with nonpregnant animals.<\/jats:p><jats:p><jats:bold>Main outcome measures\u2002<\/jats:bold> Maternal blood pressure, weight and mortality during pre\u2010 and postnatal development, maternal blood cellularity and haemodynamic changes with maternal and fetal Doppler quantitative indices.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> SC restores normal values of blood pressure, cell count and proteinuria for maternal syndrome. In offspring, SC improves weight gain and increases survival rates without fetotoxic effects. According to the haemodynamic results, SC has a significant effect on the resistance index in the uterine artery in pre\u2010eclamptic animals, as it restores normal values to correlate with an increase in fetal perfusion through the ductus venosus.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> These results suggest that SC administration during pregnancy may have a potential benefit for the treatment of hypertension during pregnancy by reversing the maternal effects of pre\u2010eclampsia and by improving uteroplacental and fetal perfusion.<\/jats:p>","DOI":"10.1111\/j.1471-0528.2012.03430.x","type":"journal-article","created":{"date-parts":[[2012,7,25]],"date-time":"2012-07-25T08:44:44Z","timestamp":1343205884000},"page":"1394-1402","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":63,"title":["Sildenafil citrate improves perinatal outcome in fetuses from pre\u2010eclamptic 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