{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T14:32:54Z","timestamp":1791210774060,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,11,6]],"date-time":"2012-11-06T00:00:00Z","timestamp":1352160000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:p><jats:bold>Objective\u2002<\/jats:bold> To study the effect of aspirin in the prevention of pre\u2010eclampsia in high\u2010risk women.<\/jats:p><jats:p><jats:bold>Design\u2002<\/jats:bold> Randomised, double\u2010blinded, placebo\u2010controlled trial.<\/jats:p><jats:p><jats:bold>Setting\u2002<\/jats:bold> Maternity clinics in ten Finnish hospitals participating in the PREDO Project.<\/jats:p><jats:p><jats:bold>Sample\u2002<\/jats:bold> A total of 152 women with risk factors for pre\u2010eclampsia and abnormal uterine artery Doppler velocimetry.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Participants were randomised to start either aspirin 100\u2003mg\/day or placebo at 12\u2003+\u20030 to 13\u2003+\u20036\u2003weeks\u2003+\u2003days of gestation. Because of the limited power of this trial, we also conducted a meta\u2010analysis of randomised controlled trials that included data on 346 women with abnormal uterine artery Doppler flow velocimetry, and aspirin 50\u2013150\u2003mg\/day started at or before 16<jats:sup>\u2003<\/jats:sup>weeks of gestation.<\/jats:p><jats:p><jats:bold>Main outcome measure\u2002<\/jats:bold> Pre\u2010eclampsia, gestational hypertension and birthweight standard deviation (SD) score. Outcome measures for the meta\u2010analysis were pre\u2010eclampsia, severe pre\u2010eclampsia, preterm (diagnosed &lt;37\u2003+\u20030\u2003weeks of gestation) and term pre\u2010eclampsia.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> From the 152 randomised women, 121 were included in the final analysis. Low\u2010dose aspirin did not reduce the rate of pre\u2010eclampsia (relative risk [RR] 0.7, 95% CI 0.3\u20131.7); gestational hypertension (RR 1.6, 95% CI 0.6\u20134.2); early\u2010onset pre\u2010eclampsia (diagnosed &lt;34\u2003+\u20030\u2003weeks of gestation) (RR 0.2, 95% CI 0.03\u20132.1); or severe pre\u2010eclampsia (RR 0.4, 95% CI 0.1\u20131.3); and the results were not statistically significant in an intention\u2010to\u2010treat analysis. However, our meta\u2010analysis, including the current data, suggested that low\u2010dose aspirin initiated before 16\u2003weeks of gestation reduces the risk of pre\u2010eclampsia (RR 0.6, 95% CI 0.4\u20130.8) and severe pre\u2010eclampsia (RR 0.3, 95% CI 0.1\u20130.7).<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Our trial showed no statistically significant effect of aspirin in preventing pre\u2010eclampsia in high\u2010risk women. However, our meta\u2010analysis suggested that aspirin may reduce the incidence of pre\u2010eclampsia.<\/jats:p>","DOI":"10.1111\/j.1471-0528.2012.03493.x","type":"journal-article","created":{"date-parts":[[2012,11,6]],"date-time":"2012-11-06T11:21:42Z","timestamp":1352200902000},"page":"64-74","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":148,"title":["Aspirin in the prevention of pre\u2010eclampsia in high\u2010risk women: a randomised placebo\u2010controlled PREDO Trial and a meta\u2010analysis of randomised trials"],"prefix":"10.1111","volume":"120","author":[{"given":"PM","family":"Villa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Kajantie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"R\u00e4ikk\u00f6nen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A\u2010K","family":"Pesonen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"H\u00e4m\u00e4l\u00e4inen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Vainio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Taipale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Laivuori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the PREDO Study group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,11,6]]},"reference":[{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2000.107928"},{"key":"e_1_2_11_3_2","volume-title":"Make Every Mother and Child Count","author":"The world health report: 2005"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)17987-2"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60712-0"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181e9322a"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1701-2163(16)34300-6"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2002.01046.x"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(03)00269-0"},{"key":"e_1_2_11_10_2","first-page":"826","article-title":"Usefulness of aspirin therapy in high\u2010risk pregnant women with abnormal uterine artery Doppler ultrasound at 14\u201316\u2003weeks pregnancy: randomized controlled clinical trial","volume":"46","author":"Ebrashy A","year":"2005","journal-title":"Croat Med J"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1997.09020094.x"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2000.104840"},{"key":"e_1_2_11_13_2","first-page":"1540","article-title":"[Characteristic of recent fetal growth curves in finland]","volume":"105","author":"Pihkala J","year":"1989","journal-title":"Duodecim"},{"key":"e_1_2_11_14_2","article-title":"Antiplatelet agents for preventing pre\u2010eclampsia and its complications","volume":"004659","author":"Duley L","year":"2007","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_11_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2005.12.006"},{"key":"e_1_2_11_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dep245"},{"key":"e_1_2_11_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deq286"},{"key":"e_1_2_11_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2010.02577.x"},{"key":"e_1_2_11_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1986.tb07830.x"},{"key":"e_1_2_11_20_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0412.1999.780202.x"},{"key":"e_1_2_11_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-006-0259-1"},{"key":"e_1_2_11_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60713-2"},{"key":"e_1_2_11_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2010.07.015"}],"container-title":["BJOG: An International Journal of Obstetrics &amp; 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