{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T18:43:31Z","timestamp":1791053011238,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"s1","license":[{"start":{"date-parts":[[2004,3,22]],"date-time":"2004-03-22T00:00:00Z","timestamp":1079913600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2004,4]]},"abstract":"<jats:p>Painful diabetic peripheral neuropathy (DPN) is described as a superficial burning pain associated with other positive and\/or negative sensory systems affecting the feet and lower extremities. It is one of the most commonly encountered neuropathic pain syndromes in clinical practice. Presentation may be complicated by multiple symptoms, including allodynia, hyperalgesia, other less well characterized dysesthesias, and serious disruption of social functioning and mood. Peripheral nerve function may deteriorate, which can account for patient reports of diminution of pain after several years of follow\u2010up. Although current understanding holds that the pathogenesis of DPN is multifactorial in nature, long\u2010term studies have shown that rigorous glycemic control is the most relevant factor in clinical intervention and can delay the onset and slow the progression of neuropathy. In addition to glycemic control, other treatment approaches must be examined in order to restore quality of life for patients experiencing painful DPN. Differential diagnosis is required to isolate DPN from other unexplained chronic pain. Neurologic testing in painful DPN is an area of active research and is used to assess the neurologic pathways giving rise to the pain, the degree of neural damage and the degree of subclinical damage. Current treatment options for DPN include mainly antidepressants and anticonvulsants, with other agents such as tramadol, dextromethorphan and memantine being employed or studied. This review article includes a case study of a patient with painful DPN to demonstrate the current management strategies for this neuropathic pain syndrome.<\/jats:p>","DOI":"10.1111\/j.1471-0552.2004.00795.x","type":"journal-article","created":{"date-parts":[[2004,3,22]],"date-time":"2004-03-22T15:57:47Z","timestamp":1079971067000},"page":"12-21","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Pain in diabetic neuropathy case study: whole patient management"],"prefix":"10.1111","volume":"11","author":[{"given":"P.","family":"Marchettini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Teloni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Formaglio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Lacerenza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,3,22]]},"reference":[{"key":"e_1_2_19_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(99)00008-X"},{"key":"e_1_2_19_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0074-7742(02)50079-9"},{"key":"e_1_2_19_4_1","doi-asserted-by":"crossref","unstructured":"BackonjaM(1999).Managing painful diabetic neuropathy.Hospital Practice79\u201388.","DOI":"10.3810\/hp.1999.10.169"},{"key":"e_1_2_19_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.280.21.1831"},{"key":"e_1_2_19_6_1","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1093\/qjmed\/91.11.733","article-title":"Diabetic peripheral neuropathy and quality of life","volume":"91","author":"Benbow SJ","year":"1998","journal-title":"Q J Med"},{"key":"e_1_2_19_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-5491.1999.00028.x"},{"key":"e_1_2_19_8_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.8.2.125"},{"key":"e_1_2_19_9_1","first-page":"279","volume-title":"Diabetes Mellitus: Theory and Practice","author":"Brownlee M.","year":"1990"},{"key":"e_1_2_19_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1991.00400110079017"},{"key":"e_1_2_19_11_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.24.1.487"},{"key":"e_1_2_19_12_1","first-page":"147","article-title":"Chronic pain in patients with diabetes mellitus; comparison with a non\u2010diabetic population","volume":"3","author":"Chan AW","year":"1990","journal-title":"Pain Clinic"},{"key":"e_1_2_19_13_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.39.1.111"},{"key":"e_1_2_19_14_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.57.3.505"},{"key":"e_1_2_19_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(01)00349-9"},{"key":"e_1_2_19_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8227(99)00112-6"},{"key":"e_1_2_19_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410370412"},{"key":"e_1_2_19_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198703053161007"},{"key":"e_1_2_19_19_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.50.6.1842"},{"key":"e_1_2_19_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002508-200006001-00017"},{"key":"e_1_2_19_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.1990.tb01451.x"},{"key":"e_1_2_19_22_1","doi-asserted-by":"publisher","DOI":"10.2165\/00002512-200118100-00003"},{"key":"e_1_2_19_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.311.7012.1047"},{"key":"e_1_2_19_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(96)03140-5"},{"key":"e_1_2_19_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002508-200112000-00002"},{"key":"e_1_2_19_26_1","unstructured":"National Diabetes Information Clearinghouse(2002).Diabetic Neuropathies: The Nerve Damage of Diabetes.Available at:http:\/\/www.niddk.nih.gov\/health\/diabetes\/pubs\/neuro\/neuro.htm. 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