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DPH had a major effect in the cerebellum and hypothalamus in that it significantly reduced cerebellar GABA. taurine and aspartate and hypothalamic GABA and aspartate. Sodium valproate significantly elevated GABA and taurine in most regions. Aspartate and glutamate were less affected. Phenobarbitone significantly elevated GABA concentrations in all brain regions, while taurine concentration was only elevated in the cerebral cortex. Ethosuximide induced changes were small compared to the other anticonvulsants while sulthiame produced complex changes. Anticonvulsant drugs administered in combination resulted in complex changes, suggesting that their mode of action is different.<\/jats:p>","DOI":"10.1111\/j.1471-4159.1981.tb01643.x","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T10:56:20Z","timestamp":1160045780000},"page":"688-695","source":"Crossref","is-referenced-by-count":72,"title":["Changes in Regional Brain Levels of Amino Acid Putative Neurotransmitters After Prolonged Treatment with t he Anticonvulsant Drugs Diphenylhydantoin, Phenobarbitone, Sodium Valproate, Ethosuximide, and Sulthiame in the Rat"],"prefix":"10.1111","volume":"36","author":[{"given":"P. N.","family":"Patsalos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. 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