{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T15:32:20Z","timestamp":1760887940790},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T00:00:00Z","timestamp":1160006400000},"content-version":"vor","delay-in-days":9135,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[1981,10]]},"abstract":"<jats:p><jats:bold>Abstract<\/jats:bold> The role of radical scavenging action in cerebral protective effect of drugs was investigated <jats:italic>in vitro.<\/jats:italic> Incubation of rat brain mitochondrial suspension with ascorbic acid and Fe<jats:sup>2+<\/jats:sup> resulted in the formation of malondialdehyde and a decrease in the turbidity of the suspension, indicating that the mitochondria were peroxidatively disintegrated. Nizofenone at 10 \u03bc<jats:sc>m<\/jats:sc> or more inhibited the peroxidative disintegration of mitochondria, and complete inhibition was observed at 100\u2013200 \u03bc<jats:sc>m<\/jats:sc>. The action of nizofenone was also ascertained by experiments with rat liver mitochondria. The anti\u2010peroxidative activity of nizofenone was estimated to be approximately equivalent to that of \u03b1\u2010tocopherol, and this property was unique. Among the cerebral protective drugs tested, thiopental was only slightly efficient, and pentobarbital, phenobarbital, and dimethyl sulfoxide had no effect. In addition, nizofenone was found to scavenge a stable free radical, diphenyl\u2010<jats:italic>p<\/jats:italic>\u2010picrylhydrazyl, but the barbiturates did not. These findings suggest that there is no intimate relationship between cerebral protective effect and free radical scavenging action.<\/jats:p>","DOI":"10.1111\/j.1471-4159.1981.tb04480.x","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T11:37:42Z","timestamp":1160048262000},"page":"934-938","source":"Crossref","is-referenced-by-count":22,"title":["Cerebral Protective Effect and Radical Scavenging Action"],"prefix":"10.1111","volume":"37","author":[{"given":"Hiroshi","family":"Yasuda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osafumi","family":"Shimada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Nakajima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takao","family":"Asano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,10,5]]},"reference":[{"key":"e_1_2_2_2_1","first-page":"269","article-title":"Barbiturate treatment of acute stroke","volume":"25","author":"Agnoli A.","year":"1979","journal-title":"Adv. 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