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Chronic daily administration of methimazole to iodide\u2010supplemented Long\u2010Evans pups or to iodine\u2010deprived Charles\u2010River rats through the first 29\u201330 days of age provoked severe hypothyroidism. Monoamine oxidase type A (MAO\u2010A) and not type B (MAO\u2010B) activity was consistently, although slightly (by approximately 20%), increased in the hypothyroid brain. Triiodothyronine (T<jats:sub>3<\/jats:sub>)\u2010induced hyperthyroidism did not affect MAO activity. Replacement therapy with T<jats:sub>3<\/jats:sub> did not normalize MAO\u2010A activity in hypothyroidism. Methimazole displayed a competitive and reversible <jats:italic>in vitro<\/jats:italic> inhibition of MAO\u2010A but not MAO\u2010B activity. Although this effect was obtained at concentrations far higher than those estimated to reach the brain after a single injection of the goiterogen, the occurrence of accumulation processes in the metabolism\u2010deficient hypothyroid neonate rs cannot be excluded. Thus, MAO\u2010A activity might be either directly depressed during the goiterogenic treatment, or increased as the result of some kind of rebound effect after interruption of methimazole administration.<\/jats:p>","DOI":"10.1111\/j.1471-4159.1983.tb08087.x","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T13:26:16Z","timestamp":1160054776000},"page":"1019-1025","source":"Crossref","is-referenced-by-count":25,"title":["Selective Effects of Neonatal Hypothyroidism on Monoamine Oxidase Activities in the Rat Brain"],"prefix":"10.1111","volume":"40","author":[{"given":"Andrea","family":"Vaccari","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Biassoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola S.","family":"Timiras","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,10,5]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1974.tb04277.x"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0301-0082(77)90010-7"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-72-17313"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1963.tb13666.x"},{"key":"e_1_2_2_6_1","first-page":"199","volume-title":"Thyroid Hormones and Brain Development","author":"Bass N. 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