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The first injection of 3\u2010NP (20\u2003mg\/kg i.p.) was followed by MRS study of neurochemicals and PET study of glucose utilization using [<jats:sup>18<\/jats:sup>F]2\u2010fluorodeoxy\u2010<jats:sc>d<\/jats:sc>\u2010glucose (<jats:sup>18<\/jats:sup>F\u2010FDG). After that, 3\u2010NP administration was done two times a day with a dose of 10\u2003mg\/kg i.p. until animals were symptomatic or for a maximum of 5\u2003days combined with daily PET studies. Long\u2010term effects were investigated 4\u2003weeks and 4\u2003months after cessation of 3\u2010NP. These studies showed a significant inter\u2010animal variation in response of 3\u2010NP toxicity. Animals that developed large striatal lesions had decreased glucose utilization in the striatum and cortex 1\u2003day after starting 3\u2010NP injections. Similarly succinate and lactate\/macromolecule levels were enhanced; these changes being, however, reversible. Progressive degeneration was observed by decreasing striatal glucose utilization and <jats:italic>N<\/jats:italic>\u2010acetylaspartate (NAA) and increasing choline. These observations paralleled with weight loss and deficits in behavior. Animals that did not develop lesions showed reversible enhancement in cortical glucose utilization and no change in striatal glucose utilization or neurochemicals or locomotor activity.<\/jats:p>","DOI":"10.1111\/j.1471-4159.2004.02408.x","type":"journal-article","created":{"date-parts":[[2004,5,14]],"date-time":"2004-05-14T15:46:52Z","timestamp":1084549612000},"page":"1206-1214","source":"Crossref","is-referenced-by-count":29,"title":["3\u2010Nitropropionic acid\u2010induced neurotoxicity \u2013 assessed by ultra high resolution positron emission tomography with comparison to magnetic resonance spectroscopy"],"prefix":"10.1111","volume":"89","author":[{"given":"Anna\u2010Liisa","family":"Brownell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y. 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