{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T23:33:59Z","timestamp":1791070439838,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2004,7,27]],"date-time":"2004-07-27T00:00:00Z","timestamp":1090886400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2004,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Poly(ADP\u2010ribose) polymerase\u20101 is over\u2010activated in the adult brain in response to ischemia and contributes to neuronal death, but its role in perinatal brain injury remains uncertain. To address this issue, 7\u2010day\u2010old wild\u2010type (<jats:italic>wt<\/jats:italic>) and PARP\u20101 gene deficient (<jats:italic>parp<\/jats:italic>+\/\u2013 and <jats:italic>parp<\/jats:italic>\u2013\/\u2013) Sv129\/CD\u20101 hybrid mice were subjected to unilateral hypoxia\u2010ischemia and histologic damage was assessed 10\u2003days later by two evaluators. Poly(ADP\u2010ribose) polymerase\u20101 knockout produced moderate but significant (<jats:italic>p\u2003&lt;<\/jats:italic>\u20030.05) protection in the total group of animals, but analysis by sex revealed that males were strongly protected (<jats:italic>p\u2003&lt;<\/jats:italic>\u20030.05) in contrast to females in which there was no significant effect. Separate experiments demonstrated that PARP\u20101 was activated over 1\u201324\u2003h in both females and males after the insult in neonatal <jats:italic>wt<\/jats:italic> mice and rats using immnocytochemistry and western blotting for poly(ADP\u2010ribose). Brain levels of NAD<jats:sup>+<\/jats:sup> were also significantly reduced, but the decrease of NAD<jats:sup>+<\/jats:sup> during the early post\u2010hypoxia\u2010ischemia (HI) phase was only seen in males. The results indicate that hypoxia\u2010ischemia activates Poly(ADP\u2010ribose) polymerase\u20101 in the neonatal brain and that the sex of the animal strongly influences its role in the pathogenesis of brain injury.<\/jats:p>","DOI":"10.1111\/j.1471-4159.2004.02547.x","type":"journal-article","created":{"date-parts":[[2004,8,16]],"date-time":"2004-08-16T14:44:00Z","timestamp":1092667440000},"page":"1068-1075","source":"Crossref","is-referenced-by-count":235,"title":["PARP\u20101 gene disruption in mice preferentially protects males from perinatal brain injury"],"prefix":"10.1111","volume":"90","author":[{"given":"Henrik","family":"Hagberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Ann","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroko","family":"Matsushita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changlian","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Lange","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malin","family":"Gustavsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc F.","family":"Poitras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ted M.","family":"Dawson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valina L.","family":"Dawson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frances","family":"Northington","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael V.","family":"Johnston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,7,27]]},"reference":[{"key":"e_1_2_20_2_1","doi-asserted-by":"publisher","DOI":"10.1006\/abio.1998.2664"},{"key":"e_1_2_20_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-4165(99)00054-9"},{"key":"e_1_2_20_4_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1022542221535"},{"key":"e_1_2_20_5_1","doi-asserted-by":"publisher","DOI":"10.2307\/3576299"},{"key":"e_1_2_20_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02454148"},{"key":"e_1_2_20_7_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199806000-00005"},{"key":"e_1_2_20_8_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI2169"},{"key":"e_1_2_20_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1074592"},{"key":"e_1_2_20_10_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj3420249"},{"key":"e_1_2_20_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2000.0742504.x"},{"key":"e_1_2_20_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1097-1089"},{"key":"e_1_2_20_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-199711000-00002"},{"key":"e_1_2_20_14_1","first-page":"3","article-title":"A potent PARP inhibitor does not affect the severity of hypoxic\u2010ischemic brain injury in the newborn rat","volume":"286","author":"Feng Y. 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